患者报告了多发性硬化症单克隆抗体治疗的磨损现象
Lindsey M Marian1, Kathleen A Harris1, Devon S Conway1
1Mellen Center for Multiple Sclerosis Treatment and Research, Cleveland Clinic Foundation, Cleveland, OH, USA.
概括
磨损现象在接受单克隆抗体治疗的多发性硬化症患者中很常见,影响了超过一半的受访者. 这种与抑郁症相关的效应显著降低了治疗满意度.
科学领域:
- 神经学 神经学
- 免疫学 免疫学 免疫学
- 药理学 药理学是指药理学的学科.
背景情况:
- 接受多发性硬化症 (MS) 单克隆抗体治疗的患者经常报告"磨损"效应.
- 这种现象发生在下一个预定的剂量之前,感知到的治疗益处减少时.
研究的目的:
- 调查使用单克隆抗体治疗的MS患者中磨损效应的流行率.
- 确定与这种效应相关的症状,其对治疗满意度的影响,以及与其发生相关的患者特征.
主要方法:
- 在接受natalizumab,ocrelizumab,ofatumumab或rituximab的患者进行了一项在线调查.
- 收集的数据包括患者的特征和单克隆抗体治疗的经验.
- 统计分析,包括后勤和线性回归,用于评估预测因素和结果,控制人口和临床因素.
主要成果:
- 超过一半的258名受访者 (54.7%) 表示经历过磨损现象.
- 疲劳是最常见的症状 (47.7%).
- 较高的抑郁症得分 (患者健康问卷-9) 与磨损效应和治疗满意度降低有显著联系.
结论:
- 磨损现象是多发性硬化症患者接受单克隆抗体治疗的普遍问题.
- 这种效应与抑郁症状的增加有关,并导致治疗满意度下降.
- 需要进一步的研究来制定减轻这种患者群体磨损效应的策略.
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