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带有SMARCA4突变的食道癌:对这种罕见实体进行叙述性审查

Jing Xu¹, Zhikai Chi¹

¹Department of Pathology, The University of Texas Southwestern Medical Center, Dallas, TX, USA.

Translational gastroenterology and hepatology

|May 8, 2024

概括

食道癌与关/非发酵糖 (SWI/SNF) 相关的,与矩阵相关的,与染色质,亚家族A,成员4 (SMARCA4) 的活性蛋白依赖调节器突变罕见且具有攻击性. 本综述讨论了它们的流行病学,诊断和不良预后,强调了进一步研究的必要性.

科学领域:

在瘤学瘤学.
遗传学遗传学是一个
病理学病理学病理学

背景情况:

带有SMARCA4突变的食道癌是一种罕见的恶性瘤.
由于其稀有性,它存在诊断方面的挑战.
了解它的特征对于患者护理至关重要.

研究的目的:

审查有关SMARCA4突变的食道癌的现有文献.
讨论它的流行病学,临床表现和病理特征.
突出诊断挑战,治疗和预后.

主要方法:

通过PubMed,Scopus,奥维迪和谷歌学者进行广泛的文献搜索.
对引用进行交叉检查,以确定所有相关的文章.
关于SMARCA4突变食道癌的已发表文献的综述.

主要成果:

在中年到老年男性中最常见,与巴雷特食道和GERD有关.
缺食症是最常见的表现;EGD是首选的诊断工具.
瘤表现出侵略性行为,晚期,预后不佳,大多数患者在一年内死亡.

结论:

带有SMARCA4突变的食道癌是一种侵袭性疾病.
需要对受影响的分子通路进行进一步的研究.
更好的理解可能会导致更好的治疗策略和预后.

关键词:

这就是BRG1的原因.消化道中的食道.这种癌症是癌症癌症.消化道 - 消化道切换/糖糖与非发酵相关的,与矩阵相关的,依赖于动蛋白的染色质调节器,亚家族A,成员4 (SMARCA4)

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