在2001-2021年期间,丹麦癌症儿童的与治疗相关的死亡率在丹麦
Marie C L Sørensen1, Mie M Andersen1, Klaus Rostgaard2
1Department of Paediatric Haematology and Oncology, Department of Paediatric and Adolescence Medicine, Juliane Marie Center, Copenhagen University Hospital, Copenhagen, Denmark; Danish Cancer Institute, Danish Cancer Society, Copenhagen, Denmark.
Acta oncologica (Stockholm, Sweden)
|May 8, 2024
概括
癌症儿童的与治疗相关的死亡人数,尽管加强了治疗,但仍然稳定. 像复发和干细胞移植这样的风险因素需要针对患者的具体方法来预防死亡.
科学领域:
- 儿科瘤学 儿科瘤学
- 癌症治疗并发症 癌症治疗并发症
- 公共卫生 公共卫生
背景情况:
- 由于强化治疗,儿童癌症的生存率有所改善.
- 强化癌症疗法可能导致致命的并发症.
- 本研究研究了2001-2021年丹麦癌症儿童与治疗相关的死亡情况.
研究的目的:
- 评估与治疗相关的死亡发生率的时间变化.
- 确定与儿童癌症患者治疗相关死亡相关的风险因素.
- 为减少与治疗相关的死亡率的策略提供信息.
主要方法:
- 对3255名在15岁之前被诊断患有癌症的儿童进行了回顾性队列研究.
- 使用阿伦-约翰森估计器估计了5年内与治疗相关的累计死亡发生率.
- 考克斯回归被用来确定相关的风险因素.
主要成果:
- 93名儿童 (占总数的2.9%) 因与治疗相关的原因死亡.
- 与治疗相关的死亡率从3.3% (2001-2010) 下降到2.5% (2011-2021).
- 风险因素包括女性性别,年轻年龄,复发,干细胞移植,中枢神经系统参与和转移.
结论:
- 在丹麦,与治疗相关的死亡率在20年内保持稳定.
- 临床警对于预防与治疗相关的死亡至关重要,特别是在血液癌症中.
- 特定于患者的治疗策略由已识别的风险因素支持.
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