雷戈拉费尼布与免疫疗法相比,单独使用雷戈拉费尼布作为肝细胞癌的二线治疗:一个多中心的现实研究
Liang Qiao1,2, Wei He1,2, Guoying Wang3,4
1State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Centre, Guangzhou, China.
Cancer medicine
|May 8, 2024
概括
将regorafenib与免疫检查点抑制剂 (ICI) 结合使用,显著改善了晚期肝细胞癌 (HCC) 患者的治疗结果. 与单独使用雷戈拉费尼布相比,这种组合疗法提供了一个更有效的二线治疗选择.
科学领域:
- 肝胆瘤学 肝胆瘤学
- 医学瘤学 医学瘤学
- 临床药理学 临床药理学
背景情况:
- 雷戈拉菲尼布是治疗晚期肝细胞癌 (HCC) 的标准二线疗法.
- 有限的现实世界数据存在于将regorafenib与免疫检查点抑制剂 (ICI) 结合在HCC.
- 评估组合疗法与单一疗法对优化HCC治疗至关重要.
研究的目的:
- 评估结合regorafenib与ICI与regorafenib单一治疗的临床益处.
- 在现实环境中评估这种组合作为高级HCC的二线治疗.
- 为了比较两种治疗策略的疗效和安全性概况.
主要方法:
- 这是一项现实研究,涉及5个医疗机构的208名高级HCC患者.
- 143名患者接受了regorafenib加ICI联合治疗;65人接受了regorafenib单一治疗.
- 使用倾向分数匹配 (PSM) 分析来最大限度地减少混因素.
主要成果:
- 雷戈拉费尼布加ICI组的客观反应率 (24.3%对10.3%) 和疾病控制率 (79.4%对50.0%) 显著更高.
- 无进展生存时间 (7.9 vs. 3.2 个月) 和整体生存时间 (25.6 vs. 16.4 个月) 的中位数在组合疗法下显著更长.
- 3-4级与治疗相关的不良事件相似 (23.8%对20.0%),没有与治疗相关的死亡率.
结论:
- 对于先进的HCC,regorafenib和ICI的联合治疗显示出与regorafenib单一治疗相比更高的疗效.
- 组合疗法表现出有利且可容忍的安全性.
- 雷戈拉费尼布加ICI代表了一个有前途的二线治疗选择,用于先进的HCC.
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