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工程化生物纳米颗粒作为瘤免疫调节的纳米疗法

Juwita N Rahmat^1,2, Jiayi Liu³, Taili Chen⁴

¹Department of Biomedical Engineering, College of Design and Engineering, National University of Singapore, Singapore 117585, Singapore.

Chemical Society reviews

|May 8, 2024

概括

生物纳米粒子 (bionanoparticles) 为癌症纳米治疗提供了一个安全有效的平台. 这些生物纳米粒子的工程可以克服瘤诱导的免疫抑制,以改善癌症的消除.

科学领域:

纳米科学和纳米技术
免疫学免疫学免疫学
生物技术是生物技术.

背景情况:

生物纳米粒子 (bionanoparticles) 是由生物系统合成的,可以为特定的功能进行工程设计.
生物纳米粒子表现出有利的特性,如免疫逃避,低毒性和生物相容性,将其定位为一个有前途的治疗平台.
癌症组织开发出机制来逃避免疫检测,并创造一个免疫抑制瘤微环境 (TME).

研究的目的:

审查瘤使用的免疫抑制机制.
为了分类调节性免疫抑制细胞和向癌症治疗的分子.
总结开发免疫调节生物粒子的工程策略,以抵消TME诱导的免疫抑制.

主要方法:

科学文献的系统审查.
免疫抑制机制,细胞参与者和分子点的分类.
对基于生物纳米粒子的免疫调节的工程策略的分析.

主要成果:

瘤诱导的免疫抑制途径的详细分类.
在免疫抑制性TME中确定关键的细胞和分子点.
对工程生物纳米粒子恢复抗瘤免疫力的当前和新兴策略的概述.

结论:

生物纳米粒子代表了癌症纳米疗法的新范式,因为它们固有的安全性和有效性.
克服瘤诱导的免疫抑制对于成功的癌症纳米疗法至关重要.
设计生物纳米粒子来调节TME具有促进癌症治疗的巨大潜力.

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