尿道微生物群在膀致癌中的潜在作用:系统性审查
Amir Ghabousian1, Ashkan Shafigh2, Sona Tayebi3
1Research Center for Evidence-Based Medicine, Iranian EBM Centre: JBI Centre of Excellence, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran. Amir.ghabousian@yahoo.com.
Urology journal
|May 8, 2024
概括
膀癌 (BC) 患者的尿路微生物群组成发生了变化,但研究结果有显著的差异. 需要更多的研究来证实尿路微生物在BC发展和进展中的作用.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 微生物学 微生物学
- 在瘤学瘤学.
背景情况:
- 尿道微生物群在膀癌 (BC) 发病,侵袭性和转移中的作用正在调查中.
- 了解这些微生物转变对于开发新型诊断和治疗策略至关重要.
研究的目的:
- 系统地审查和定量评估尿路微生物群在膀癌 (BC) 致癌,侵袭性,进展和转移中的潜在作用.
- 识别与BC发育和临床结果相关的特定微生物特征.
主要方法:
- 按照PRISMA和乔安娜·布里格斯研究所 (JBI) 的指导方针进行了系统审查.
- 进行了对公布和未公布研究的全面搜索,直到2024年1月.
- 使用JBI评估检查表来评估包含的研究中的潜在偏见.
主要成果:
- 该审查分析了27项涉及926名BC患者和412名对照者的研究.
- 在癌症和健康样本之间,或在各种临床子组之间,没有发现微生物α多样性的统计学上显著差异.
- 在一些研究中,β-多样性分析显示了BC患者和对照人群之间的显著差异,但在不同的临床参数和采集方法中,结果不一致.
结论:
- 在膀癌患者中,尿路微生物群的组成发生了变化.
- 研究中的显著异质性阻止了关于特定微生物变化的最终结论.
- 进一步的精心设计的研究对于阐明尿道微生物群在BC癌症发生和进展中的作用至关重要.
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