使用全球触发器工具探索急性精神病发作儿童不良反应的危险因素:年龄是否重要?
Dmitriy V Ivashchenko1, Nina I Buromskaya2, Pavel V Shimanov2
1Child Psychiatry and Psychotherapy Department, Russian Medical Academy of Continuous Professional Education, Moscow, Russia.
概括
青春期,多药和首次住院增加了急性精神病的抗精神病药物不良反应 (ADEs). 不管药物剂量如何,13岁以下的儿童经历的副作用较少.
科学领域:
- 药物监督 药物监督 药物监督
- 儿科精神病学 儿科精神病学
- 临床药理学 临床药理学
背景情况:
- 抗精神病药物对于治疗儿童和青少年急性精神病发作至关重要.
- 了解药物不良反应 (ADEs) 的风险因素对于优化这一群体的治疗安全至关重要.
研究的目的:
- 确定与急性精神病抗精神病治疗的儿科和青少年患者中药物不良反应 (ADEs) 的发生相关的重大风险因素.
主要方法:
- 对450名患者记录 (2016-2018) 的回顾性审查,使用全球触发工具方法来检测潜在的ADE.
- 患者被分为"儿童" (12岁以下) 和"青少年" (13岁及以上) 组.
- 使用后勤回归分析来确定ADE的预测因素.
主要成果:
- 在28%的患者病历中发现了不良药物效应 (ADEs).
- 青少年 (13岁以上) 与儿童 (年龄在12岁以下,13.8%) 相比,ADE的发生率显著更高 (30.4%).
- 确定的主要危险因素是青春期 (OR=2.58),多药 (OR=1.96) 和首次住院 (OR=2.17).
结论:
- 青春期,多药和初次住院是急性精神病中与抗精神病药物相关的ADE的重要预测因素.
- 较年轻的儿童 (<13岁) 似乎有较低的ADE风险,无论药物剂量或类型.
- 这些发现凸显了青少年患者和复杂药物治疗方案患者或首次入院期间需要有针对性的监测的需要.
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