确定可修改的风险因素,以预防侵袭性结肠直肠癌
Peilu Wang1, Mingyang Song2,3,4,5, A Heather Eliassen2,3,6
1Department of Nutrition and Food Hygiene, School of Public Health, Institute of Nutrition, Fudan University, Shanghai, China.
International journal of cancer
|May 8, 2024
概括
预诊断因素,如饮食和阿司匹林使用,影响了侵袭性结肠直肠癌 (CRC) 的发展. 生活方式的选择可能会影响瘤的攻击性,为CRC预防策略提供新的途径.
科学领域:
- 在瘤学瘤学.
- 癌症流行病学 癌症流行病学
- 预防医学 预防医学
背景情况:
- 预诊断因素对侵袭性结直肠癌 (CRC) 的发展的影响在很大程度上是未知的.
- 了解这些因素对于制定针对性预防策略对抗侵袭性瘤亚型至关重要.
- 具有迅速进展和不良结果的侵略性CRC构成了重大的公共卫生挑战.
研究的目的:
- 调查31种预诊断风险因素与侵袭性结肠直肠癌 (CRC) 风险之间的关联.
- 为了比较这些风险因素对攻击性CRC和非攻击性CRC的影响.
- 确定影响CRC瘤攻击性的潜在可修改的风险因素.
主要方法:
- 对205,489名美国卫生专业人员进行前性队列研究.
- 分析了3201例CRC病例,其中899例基于5年内的死亡率,致命结果或瘤阶段被归类为侵略性.
- 数据增强方法用于评估与攻击性与非攻击性CRC终点的风险因素关联的差异.
主要成果:
- 下部内镜检查和定期使用阿司匹林的保护性关联在攻击性CRC与非攻击性CRC相比更强烈.
- 较低的全谷物/谷物纤维摄入量和更高的饮食炎症潜力与增加的侵略性CRC风险有关.
- 积极的CRC病例显示KRAS突变的患病率较高,远端或MSI高瘤的患病率较低.
结论:
- 预诊断风险因素,包括生活方式和饮食模式,似乎在侵袭性CRC的发病过程中发挥作用.
- 研究结果表明,特定的风险因素可能会影响瘤的攻击性,与整体CRC风险不同.
- 这些见解可以指导未来的研究,并为旨在减少侵略性CRC发病率和死亡率的预防性干预提供信息.
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