对于具有焦点细分型淋巴结核硬化病变的异常性膜性脏病,可能需要积极的治疗
Ping Cheng1, Qionghong Xie1, Shaojun Liu1
1Huashan Hospital Affiliated to Fudan University, Department of Nephrology - Shanghai, China.
Revista da Associacao Medica Brasileira (1992)
|May 8, 2024
概括
具有焦点细分结核硬化 (FSGS) 病变的异常膜性病症呈现出更严重的病综合征和更差的功能. 建议对这些患者进行积极的免疫抑制治疗,以防止衰退.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 病理学 病理学 病理学
- 临床医学 临床医学
背景情况:
- 异形膜性病 (IMN) 是成年人性综合征的主要原因.
- 在IMN中,焦点细分型血小板硬化 (FSGS) 病变的同时存在可能会改变其临床表现和预后.
研究的目的:
- 分析IMN与共存FSGS病变的临床,病理,预后特征和治疗反应.
主要方法:
- 一项回顾性队列研究,涉及236名IMN患者,分为具有 (FSGS+) 和没有 (FSGS-) FSGS病变的组.
- 实验室数据的比较,病理发现 (包括新月,间歇性纤维化和IMN阶段) 和脂酶A2受体 (PLA2R) 状态.
- 在随访期间评估治疗效果和功能.
主要成果:
- FSGS+组的高血压率更高,蛋白质尿症更严重,白蛋白水平更低,估计的膜过率 (eGFR) 降低.
- 在病理上,FSGS+患者表现出更多的新月,间歇性纤维化和先进的IMN阶段,PLA2R阳性率较低.
- 非免疫抑制的FSGS+患者有延迟缓解和更高的功能恶化率;免疫抑制组显示了类似的缓解率.
结论:
- 与FSGS病变相关的IMN与单独IMN相比,与更严重的脏综合征和较差的功能有关.
- 考虑更积极的免疫抑制疗法是有必要的IMN患者与FSGS病变,以减轻功能下降.
相关概念视频
01:27Open Angle Glaucoma: Treatment
432
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Drugs such as carbonic anhydrase inhibitors, α2- and...
432
01:28Angle Closure Glaucoma: Treatment
480
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
480