与自身免疫相关的LINC01934和AP002954.4 lncRNA多态可能在儿科腹腔疾病中有效:一个病例控制研究
Seda Orenay-Boyacioglu1, Guzide Dogan2,3, Metin Caliskan1,4
1Aydın Adnan Menderes University, Faculty of Medicine, Department of Medical Genetics, - Aydın, Turkey.
Revista da Associacao Medica Brasileira (1992)
|May 8, 2024
概括
某些长非编码RNA (lncRNA) 多态,特别是LINC01934-rs1018326和AP002954.4-rs10892258,与儿科腹腔疾病的风险增加有关. 这些发现表明,这些lncRNA遗传变异在这种自身免疫性疾病的发展中可能发挥作用.
科学领域:
- 遗传学 是一个遗传学.
- 免疫学 免疫学 免疫学
- 胃肠病学 胃肠病学
背景情况:
- 在腹腔疾病患者的肠道中观察到某些长非编码RNA (lncRNAs) 的水平降低,暗示与肠道炎症有关.
- lncRNAs在自身免疫性疾病 (包括乳病) 的病原发生过程中的确切作用需要进一步研究.
研究的目的:
- 调查特定长非编码RNA多态和被诊断患有乳症的儿童自身免疫之间的关联.
- 评估 lncRNA 遗传变异对儿科队列中乳病发展的潜在贡献.
主要方法:
- 从88名儿科腹腔疾病患者和74名健康对照者的组织样本中提取了DNA.
- 使用TaqMan试验进行了五种单核酸多态 (SNPs) 在lncRNA中的基因定型 (LINC01934-rs1018326,IL18RAP-rs917997,AP002954.4-rs10892258,UQCRC2P1-rs6441961和HCG14 rs3135316).
主要成果:
- 在胰腺疾病患者和对照人群 (p<0.05) 之间的LINC01934-rs1018326和AP002954.4-rs10892258多态体中,发现了基因型和等位基因频率的统计学上显著差异.
- 在LINC01934-rs1018326多态性与1.14倍的风险 (衰退模型) 和1.2倍的风险 (添加模型) 相关的儿科腹腔疾病.
- AP002954.4-rs10892258的多态性显示,在儿科腹腔疾病中,风险是1.40倍 (主导模型) 和1.7倍 (附加模型).
结论:
- 在LINC01934-rs1018326和AP002954.4-rs10892258的多形态被突出显示为在儿科乳病的背景下潜在的重要.
- 这些发现表明,这些特定的lncRNA多态化与性疾病等自身免疫性疾病所涉及的炎症过程之间可能存在联系.
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