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Updated: May 6, 2026

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Ex Vivo Corneal Organ Culture Model for Wound Healing Studies
Published on: February 15, 2019
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在三种不同的激光角膜折射手术中,角膜生物机械反应
概括
Femtosecond激光辅助激光 in situ keratomileusis (FS-LASIK) 显著影响手术后的角膜硬,随后是小切口镜片提取 (SMILE) 和横光折射性角膜切除术 (tPRK). 更新的应力-应变指数 (SSIv2) 显示了测量角膜材料刚度不受折射手术影响的前景.
科学领域:
- 眼科医生 眼科 眼科
- 生物机械工程 生物机械工程
- 角膜外科手术 角膜外科手术
背景情况:
- 折射手术改变了角膜生物力学.
- 了解这些变化对于患者的治疗结果至关重要.
研究的目的:
- 为了比较横体光折射性角膜切除术 (tPRK),女性秒激光辅助激光在位角膜切除术 (FS-LASIK) 和小切口镜片提取 (SMILE) 对角膜生物力学的影响.
主要方法:
- 207名患者接受了tPRK,FS-LASIK或SMILE.
- 用Corvis ST (Oculus Optikgeräte GmbH) 在手术前和手术后3个月和6个月测量角膜生物力学.
- 分析的关键参数包括DAR2,IIR,SP-A1,HCT和SSIv2,以及CCT和DCT-IOP.
主要成果:
- SP-A1下降,而DAR2和IIR在术后增加,这表明刚性丧失.
- FS-LASIK对角膜硬度产生了最显著的影响,其次是SMILE,然后是tPRK.
- SSIv2的变化不那么明显,并且独立于CCT和DCT-IOP.
结论:
- SSIv2 是对角膜材料刚性的有希望的测量标准,不受折射手术的影响.
- FS-LASIK对角膜硬度的影响最大,其次是SMILE和tPRK.
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