在多发性硬化症中对认知功能的最小评估进行有意义的认知变化
Emilio Portaccio1, Paola Grossi2, Fabio Bellomi3
1Department of Neurofarba, University of Florence, Florence, Italy.
Multiple sclerosis (Houndmills, Basingstoke, England)
|May 8, 2024
概括
这项研究提供了评估多发性硬化症 (MS) 认知变化的规范性数据,使用MS认知功能的最小评估 (MACFIMS). 这些发现提高了MS患者随时间推移的认知表现的解释.
科学领域:
- 神经科学是一个神经科学.
- 认知心理学 认知心理学
- 临床神经学 临床神经学
背景情况:
- 解释多发性硬化症 (MS) 随着时间的推移的认知变化,由于有限的规范性数据,提出了挑战.
- 精确评估认知功能对于管理多发性硬化症进展和治疗疗效至关重要.
研究的目的:
- 在MS认知功能的最小评估 (MACFIMS) 内的所有测试中建立统计学上显著的认知变化检测的规范数据.
- 通过提供标准化解释指南,提高MS认知评估的可靠性.
主要方法:
- 在一个健康的意大利队列中使用了可靠的变化方法,每隔一年给予MACFIMS的替代版本.
- 使用可靠变化指数 (RCI) 计算了重新测试得分差异的置信区间.
- 开发了多变量线性回归模型,根据年龄,性别,教育和基线得分进行调整,以计算基于回归的变化指数 (RB-CI).
主要成果:
- 招募了200名健康个体,并确定了解释每个MACFIMS测试中变化的值.
- 基线分数显著预测了所有测试中的重复测试分数 (B从0.439到0.760;p <0.001).
- 该研究证实了使用开发的多变量模型计算RB-CI的可行性.
结论:
- 现在可以获得所有MACFIMS测试中可靠认知变化评估的规范性数据.
- 这包括广泛使用的工具,如符号数字模式测试和MS的简要国际认知评估.
- 预计这些发现将显著改善MS患者认知变化的解释.
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