在病毒感染中,帕萨斯佩克尔成分的参与
Romane Milcamps1, Thomas Michiels1
1Université catholique de Louvain, de Duve Institute, Brussels, Belgium.
Nucleus (Austin, Tex.)
|May 8, 2024
概括
由NEAT1 lncRNA和DBHS蛋白质构建的寄生虫,通过调节基因表达和翻译来影响病毒感染. 这些核体调节干扰素反应,影响病毒动态.
科学领域:
- 细胞生物学 细胞生物学
- 病毒学 病毒学
- 分子生物学分子生物学
背景情况:
- 抛光斑是由NEAT1 lncRNA和DBHS蛋白 (PSPC1,SFPQ,NONO) 组成的核体.
- 抛光斑组件涉及到各种细胞过程,包括RNA代谢和基因调节.
- 新出现的证据表明,斑在抗病毒免疫力中起着作用.
研究的目的:
- 审查斑在病毒感染中的多面性作用.
- 阐明虫调节宿主抗病毒反应的机制.
- 突出NEAT1和DBHS蛋白对病毒动态的贡献.
主要方法:
- 对调查和病毒感染的研究进行文献综述.
- 分析包括基因表达,翻译和mRNA处理在内的机制.
- 检查cGAS-STING通路与紫光斑的相互作用.
主要成果:
- 寄生虫通过抗病毒基因诱导,IRES介导的翻译和病毒mRNA多化影响病毒感染.
- 该NEAT1-paraspeckle复合体通过cGAS-STING轴调节干扰素基因转录.
- 抛光斑蛋白对于调节宿主对病毒病原体的反应至关重要.
结论:
- 假是宿主抗病毒状态的关键调节者.
- NEAT1 lncRNA和DBHS蛋白质是控制病毒感染结果的关键组成部分.
- 准紫外线的功能是抗病毒疗法的潜在策略.
关键词:
干扰素 干扰素 干扰素在NEAT1中,NEAT1是NEEAT1的.在SFPQQ中,SFPQ是最重要的.内部核糖体进入部位 (IRES)长非编码RNA是什么意思这里有很多种类的虫, paraspeckles.病毒复制病毒复制病毒病毒病毒病毒.更多相关视频
07:24Single-Cell Multiplexed Fluorescence Imaging to Visualize Viral Nucleic Acids and Proteins and Monitor HIV, HTLV, HBV, HCV, Zika Virus, and Influenza Infection
Published on: October 29, 2020
2.7K
11:28Dissecting Host-virus Interaction in Lytic Replication of a Model Herpesvirus
Published on: October 7, 2011
11.0K
相关概念视频
Viral Structure
62.1K
Viruses are extraordinarily diverse in shape and size, but they all have several structural features in common. All viruses have a core that contains a DNA- or RNA-based genome. The core is surrounded by a protective coat of proteins called the capsid. The capsid is composed of subunits called capsomeres. The capsid and genome-containing core are together known as the nucleocapsid.
62.1K
Immune Response Against Viral Pathogens
776
The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
776
Leaky Scanning
5.1K
During most eukaryotic translation processes, the small 40S ribosome subunit scans an mRNA from its 5' end until it encounters the first start AUG codon. The large 60S ribosomal subunit then joins the smaller one to initiate protein synthesis. The location of the translation initiation is largely determined by the nucleotides near the start codon as there may be multiple translation initiation sites present on the mRNA. Marilyn Kozak discovered that the sequence RCCAUGG (where R...
5.1K
Viral Recombination
23.4K
Cells are sometimes infected by more than one virus at once. When two viruses disassemble to expose their genomes for replication in the same cell, similar regions of their genomes can pair together and exchange sequences in a process called recombination. Alternatively, viruses with segmented genomes can swap segments in a process called reassortment.
23.4K
Intracellular Movement of Viruses and Bacteria
2.8K
Intracellular bacteria and viruses often comprise a group of highly infectious pathogens that can cause several diseases. Bacterial pathogens include those belonging to the genus Rickettsia responsible for conditions such as rocky mountain spotted fever and the Mediterranean spotted fever; Chlamydia, a genus responsible for a sexually transmitted disease; Coxiella burnetii, an agent responsible for Q fever. Viral pathogens include vaccinia—a poxvirus, and herpes simplex virus—a...
2.8K
What are Viruses?
114.8K
Overview
114.8K
