黑色素保护斑马鱼的胰腺发育和生理节奏免受基酸诱导的干扰,通过下丘脑-垂体-甲状腺轴
Yixin Xu1, Shuhui Zhang1, Yehua Bao1
1College of Life Science, State Key Laboratory of Medicinal Chemical Biology, The Key Laboratory of Bioactive Materials, Ministry of Education, Nankai University, Tianjin, China.
Journal of the science of food and agriculture
|May 8, 2024
概括
酸会破坏斑马鱼的昼夜节律和胰腺发育. 黑色素治疗通过调节甲状腺系统来减轻这些影响,提供潜在的治疗益处.
科学领域:
- 内分泌学 在内分泌学.
- 发展生物学 发展生物学
- 时间生物学 时间生物学
背景情况:
- 酸是一种常见的食品防腐剂,引起了公众健康的关注.
- 它对生物系统的影响,特别是昼夜节律和器官发育,需要研究.
研究的目的:
- 评估 propionate 对斑马鱼昼夜节律和胰腺发育的影响.
- 阐明底层机制,包括甲状腺内分泌系统的作用.
主要方法:
- 斑马鱼模型用于分析昼夜行为和基因表达.
- 暴露后的胰腺形态和发育基因表达的评估.
- 测量甲状腺激素水平和下丘脑-垂体-甲状腺轴基因表达.
主要成果:
- 酸暴露破坏了斑马鱼的节奏行为,并改变了关键的节奏基因.
- 胰腺形态和发育基因表达受到显著影响.
- 甲状腺激素水平和甲状腺轴基因表达失调;黑激素 (1μmol/L) 改善了这些影响.
结论:
- propionate 诱导昼夜节律障碍和胰腺发育障碍.
- 黑色素通过甲状腺系统调节来减轻这些不良影响,证明了治疗潜力.
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