最近在基于纳米配方的癌症免疫治疗中取得的进展
Seyedeh Saimeh Bokhari1, Tayyab Ali1, Muhammad Naeem2
1Clinico-Molecular Biochemistry Laboratory, Department of Biochemistry, University of Agriculture, 38000, Faisalabad, Pakistan.
Nanomedicine (London, England)
|May 8, 2024
概括
通过纳米技术输送的药用植物化合物为癌症治疗提供了一种有前途的新方法. 这些纳米配方选择性地向癌细胞,可能会彻底改变癌症免疫疗法.
科学领域:
- 纳米技术纳米技术
- 药理学 药理学是指药理学的学科.
- 在瘤学瘤学.
背景情况:
- 癌症仍然是全球主要的死亡原因之一,这给治疗带来了重大挑战.
- 来自药用植物的植物成分正在探索新的治疗应用.
研究的目的:
- 在癌症治疗中审查植物中介纳米配方的细胞和分子机制.
- 探索这些新型纳米载体的治疗前景,用于癌症免疫治疗.
主要方法:
- 对植物衍生纳米颗粒向癌症的文献综述.
- 分析包括PI3K/Akt/mTOR通路调节,反应性氧物种生成和亡诱导在内的机制.
- 对各种癌细胞系 (例如HT-29,MCF-7,HepG2,HeLa) 的疗效评估.
主要成果:
- 植物介导的纳米配方证明了对各种癌症细胞系的选择性向.
- 机制包括PI3K/Akt/mTOR通路的抑制,β-catenin的抑制,DNA损伤和亡的诱导 (caspase 3/9,p53).
结论:
- 来自植物的纳米配方显示出作为向癌症治疗的巨大潜力.
- 这些纳米载体可以通过选择性细胞杀死导致癌症免疫疗法的范式转变.
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