用单点氧生成制造碳点的制造及其潜在的光动力学治疗应用
Pengli Zuo1, Jun Peng2, Yuyang Yao3
1Central Laboratory, Linyi Central Hospital, Yishui County, 17 Jiankang Road, Linyi, 276400, Shandong, China. zuo2258960@126.com.
Journal of fluorescence
|May 8, 2024
概括
用添加的碳点 (CD) 用一种简单,经济高效的方法合成. 这些CD显示希望作为光动力学疗法 (PDT) 的光敏化剂在癌症治疗中,由于它们的低毒性和对癌细胞的有效性.
科学领域:
- 材料科学 材料科学 材料科学
- 纳米技术纳米技术
- 生物医学工程 生物医学工程
背景情况:
- 碳点 (CD) 具有独特的化学和生物医疗特性,在生物成像,传感和药物输送中发现应用.
- CDs可以作为光敏剂,产生用于光动力学治疗 (PDT) 的反应性氧物种 (ROS).
- 高成本和复杂的制造限制了当前的CD应用.
研究的目的:
- 开发一种简单且具有成本效益的方法,用于合成用于光动力学治疗 (PDT) 的碳点 (CD).
- 建立合成CD的应用作为光敏感剂用于体外抗瘤细胞治疗.
- 描述制造的CD的光物理和纳米尺度特性.
主要方法:
- 简单的单溶热合成N-化碳点 (CDs) 使用1-氨基甲基前体.
- 使用传输电子显微镜 (TEM),紫外线可见,光和FT-IR光谱学进行表征.
- 实验室光动力学疗法 (PDT) 对癌细胞进行635nm激光照射的研究.
主要成果:
- 合成的N-化CD是水溶性的,呈现黄色光辐射 (λmax = 587 nm),并具有非常低的生物毒性.
- 制造的CD显示单片氧的高产率为35%.
- 在激光照射时观察到对癌细胞的显著光毒性,证实了PDT的有效性.
结论:
- 通过溶热方法,可以有效地从单个前体中合成N-化碳点.
- 这些CD显示出在体外光动力疗法 (PDT) 中作为有效的光敏化剂的潜力.
- 合成的CD代表了未来体内PDT应用的有前途的治疗药物.
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