干扰素诱导的跨膜蛋白-3 Rs12252-G 变种在埃及人口中增加了COVID-19死亡潜力
Sara M Elessawy1, Abeer Shehab1, Dina A Soliman1
1Department of Clinical Pathology, Allergy and Clinical Immunology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Viral immunology
|May 8, 2024
概括
干扰素诱导的跨膜蛋白-3 (IFITM3) rs12252 G等位基因变体与COVID-19死亡率的增加有关. 这项研究没有发现与埃及患者的疾病严重程度或IL-6水平有显著的关联.
科学领域:
- 遗传学和分子生物学
- 传染性疾病 传染性疾病
- 免疫学 免疫学 免疫学
背景情况:
- 冠状病毒疾病2019 (COVID-19) 构成了全球健康威胁.
- 干扰素诱导的跨膜蛋白-3 (IFITM3) 基因变异可能会影响对严重病毒感染的易感性.
- IFITM3 rs12252单核酸多态 (SNP) 已与病毒性疾病的结果有关.
研究的目的:
- 调查IFITM3 rs12252A>G SNP与埃及队列中的COVID-19严重程度和死亡率之间的关联.
- 探索这种SNP,血清中白蛋白-6 (IL-6) 水平和COVID-19患者的重症监护室 (ICU) 住院之间的关系.
主要方法:
- 一项涉及100名埃及COVID-19患者的横截面研究.
- 使用实时聚合酶连锁反应的IFITM3 rs12252 SNP的基因定型.
- 通过ELISA量化血清IL-6水平.
主要成果:
- IFITM3 rs12252 A等位基因占主导 (92.5%),G等位基因在7.5%中存在.
- 在IFITM3 rs12252 SNP和COVID-19严重程度,ICU入院或IL-6水平之间没有发现显著的关联.
- 观察到G等位基因与COVID-19死亡率增加 (p=0.024) 之间存在显著的关联,死亡患者 (24.2%) 与治愈患者 (8.5%) 相比,死亡患者的频率更高.
结论:
- IFITM3 rs12252的G等位基因变异与COVID-19患者的死亡率更高显著相关.
- 在这个队列中,IFITM3 rs12252多态性与疾病严重程度,ICU入院或IL-6水平没有显著联系.
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