免疫记忆塑造了人类对H2N2疫苗接种的多克隆抗体反应
Yuhe R Yang1, Julianna Han2, Hailee R Perrett2
1Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA; Chinese Academy of Sciences Key Laboratory of Nanosystem and Hierarchical Fabrication, National Center for Nanoscience and Technology, Beijing 100190, China.
之前接触H2型流感会影响疫苗的反应. 在没有H2的个体中,疫苗针对的是保留区域,而暴露于H2的成年人则对血凝素的抗体反应更广泛.
科学领域:
- 病毒学 病毒学
- 免疫学 免疫学 免疫学
- 疫苗学 疫苗学 疫苗学
背景情况:
- 流感A型病毒亚型H2N2导致了1957年的流行病,并仍然是一个全球健康问题.
- 了解免疫记忆对于开发有效的流感疫苗至关重要.
研究的目的:
- 描述由H2血凝素 (HA) 费里纳米粒子疫苗引起的免疫记忆的结构和生化特性.
- 调查H2-naive和H2-暴露成人的多克隆血清抗体反应的广度和多样性.
主要方法:
- 一期临床试验,对未接触H2和接触H2的成年人进行.
- 血清抗体反应的综合结构和生化特征.
- 疫苗接种后针对抗体的表位的时间映射.
- 低温电子显微镜和单克隆B细胞隔离.
主要成果:
- 与H2无接触的参与者相比,暴露于H2的成年人对可变HA头部域的反应更高.
- 在H2原始个体中的初始反应主要是由针对保存表位的抗体主导的.
- 低温EM和B细胞分析显示,交叉反应性抗体向保存的表位,包括受体结合部位和HA头部的中间结点.
结论:
- 预先存在的流感暴露显著影响接种疫苗后的血清抗体反应.
- 疫苗接种策略可能需要考虑最佳免疫性之前的暴露史.
- 鉴定HA上的保存表位和脆弱部位可以为未来的疫苗设计提供信息.
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