循环时钟控制的内分泌和细胞因子信号调节骨髓中的多潜在的先天性淋巴细胞原始体
Qingyang Liu1, Shams Tabrez2, Patrick Niekamp2
1Department of Pathology, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA; Mary H. Weiser Food Allergy Center, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA; Immunology Graduate Program, University of Michigan, Ann Arbor, MI 48109, USA.
Cell reports
|May 8, 2024
概括
身体的内部时钟控制着免疫细胞从骨髓释放出来. 这一发现揭示了昼夜节律如何影响免疫细胞的产生,并随着时间的推移保持免疫健康.
科学领域:
- 免疫学 免疫学 免疫学
- 时间生物学 时间生物学
- 细胞生物学 细胞生物学
背景情况:
- 天生的淋巴细胞 (ILC) 是关键的免疫细胞,随着年龄的增长而下降.
- 从骨髓中调动ILC原始体 (ILCP) 是一个潜在的策略来抵消ILC下降.
- 激发ILCP动员的触发因素在很大程度上是未知的.
研究的目的:
- 研究昼夜时钟在调节骨髓ILCP动员中的作用.
- 为了识别控制ILCP保留和迁移的分子线索.
- 了解昼夜信号如何促进ILC种群的恒温维持.
主要方法:
- 从野生类型和生理时钟有缺陷的小鼠中分析ILCP.
- 研究与细胞贩运和昼夜调节相关的基因和蛋白质表达.
- 评估特定信号通路 (葡萄糖皮质体受体,IL-18,RORα) 对ILCP行为的影响.
主要成果:
- 循环时钟有缺陷的ILCPs表现出受损的迁移和减少成熟ILCs的产生.
- 特定的内分泌 (葡萄糖皮质体受体) 和细胞因子 (IL-18,RORα) 信号以时间依赖的方式调节ILCP保留 (通过CXCR4) 和迁移 (通过S1PR1).
- 这些信号的每日波动决定了ILCPs从骨髓到外围组织的移动.
结论:
- 生物钟在骨髓ILCPs的日常动员中发挥着至关重要的作用.
- 循环节调节的信号通路对于保持健康的ILCs池至关重要.
- 这些发现凸显了昼夜节律在免疫平衡和原生细胞贩运中的重要性.
关键词:
CP: 免疫学 免疫学CP:新陈代谢过程中的新陈代谢.它们的IL-18型.ILC 的祖先是 ILC 的祖先.在 ILCP 中,ILCP 具有很大的影响力.RORα 是一个RORα.骨髓 骨髓 骨髓 骨髓 骨髓昼夜时钟是生物周期的时间表.葡萄糖皮质类药物动员 动员 动员 动员更多相关视频
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