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通过扩散张力磁共振成像揭示与过度活跃的膀相关的大脑白物质区域的结构变化:来自下泌尿道功能障碍症状的发现研究网络横截面案例对照研究

H Henry Lai¹, Jerrel Rutlin², Abigail R Smith³

¹Division of Urologic Surgery, Departments of Surgery and Anesthesiology, Washington University School of Medicine, St Louis, Missouri.

The Journal of urology

|May 8, 2024

概括

膀过活 (OAB) 患者表现出大脑白质异常. 更严重的OAB症状与大脑通道的更大的微观结构变化相关,特别是在紧急情况的小组中.

科学领域:

神经成像是一种神经成像.
泌尿器科泌尿器科泌尿器科泌尿器科
神经学神经学

背景情况:

过度活性膀 (OAB) 是一种以尿急性为特征的疾病.
目前尚不完全了解OAB的潜在神经机制.
调查大脑结构变化可能为OAB病理生理学提供见解.

研究的目的:

用扩散张力成像 (DTI) 来研究大脑白质道的结构变化,用于患有过度活性膀 (OAB) 的患者.

主要方法:

一项涉及寻求治疗的OAB患者和匹配的对照者的横截面病例控制研究.
获得脑DTI扫描来评估白质的微结构完整性,使用分数异构性 (FA) 和平均扩散性.
使用经过验证的调查问卷评估了OAB和紧急尿失禁 (UUI) 症状.

主要成果:

与对照组相比,OAB患者表现出FA降低和平均扩散度增加,表明白质异常.
这些异常被观察到在特定的路径,包括体,前胸膜辐射,上纵侧囊,胰岛和副海马区域.
只有尿急 (OAB-干) 亚组导致了DTI差异,而不是UUI (OAB-湿) 亚组.

结论:

膀过活的患者表现出特定大脑白质道的微观结构完整性异常.
增加OAB症状的严重程度与这些微观结构异常的更大程度有关.

关键词:

大脑MRI脑部MRI脑部扩散张力成像扩散张力成像过度活动的膀紧急情况下尿失禁尿失禁.

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