通过脂质体封装来改善贝卡林的物理化学特性和细胞毒性
Wei Wang1, Xuan Xin1, Mengmeng Zhang2
1College of Light Industry and Food Technology, Guangdong Key Laboratory of Science and Technology of Lingnan Special Food, Zhongkai University of Agriculture and Engineering, Guangzhou, Guangdong, China.
Journal of microencapsulation
|May 8, 2024
概括
脂质体封装改善了黄类糖化物的稳定性和水溶性,降低了它们在食品应用中的细胞毒性. 这种方法提高了这些化合物的输送和有效性.
科学领域:
- 食品科学 食品科学 食品科学
- 生物技术是生物技术.
- 药物输送系统 药物输送系统
背景情况:
- 黄类甘油酸在食品应用中面临局限性,原因是键不稳定性,水溶性差,细胞毒性高.
- 制定克服这些挑战的策略对于扩大食品工业中黄类甘油酸的使用至关重要.
研究的目的:
- 通过脂质体封装,增强黄类甘氨酸的特性,特别是贝卡林丁烯 (BEC4) 和乙烯 (BEC8).
- 评估脂质体封装对这些改性黄的稳定性,溶解性,细胞毒性和释放特征的影响.
主要方法:
- 使用脂质体封装方法,将贝卡林丁乙烯 (BEC4) 和乙乙烯 (BEC8) 结合在一起.
- 福利埃变换红外光谱法 (FTIR) 用于确定脂质体内的的位置.
- 封装效率,装载效率和泄漏率被量化.
- 在模拟的消化系统和酸盐缓冲盐水 (PBS) 中评估了稳定性.
- 评估了细胞毒性,并研究了胃肠道消化过程中的释放动力学.
主要成果:
- 与原生baicalin相比,脂质细胞封装导致BEC4和BEC8的封装和加载效率更高.
- FTIR分析证实,BEC4和BEC8位于脂质体的疏水层中.
- 封装的BEC4和BEC8在消化液和PBS中显示出更好的水溶性和稳定性.
- 脂酶封装显著降低了BEC4和BEC8.8的细胞毒性.
- 在模拟胃肠道消化过程中,脂质体中BEC4和BEC8的释放速度较慢.
结论:
- 脂质体封装有效地解决了黄类糖化物的局限性,例如不稳定性和低溶解性.
- 这种方法提高了类甘氨酸的生物可用性和安全性,为潜在的食品工业应用.
- 脂质体技术为改善改性天然化合物的功能和适用性提供了一个有希望的策略.
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