血液凝结成一种粘合凝,用基于阴离子/阴离子多糖和拉波尼特的静血粉进行凝结
Yan Fang1, Yukai Lin1, Linyu Wang1
1College of Chemistry and Materials Science, Fujian Normal University, Fujian 350007, China.
Biomacromolecules
|May 8, 2024
概括
一种新的混合动力止血粉末 (QAL) 通过形成强大的粘合性血液凝,显著改善了紧急出血控制. 与现有治疗方法相比,这种先进的静血剂表现出优越的性能,增强的粘附性和抗菌性质.
科学领域:
- 生物材料科学 生物材料科学
- 生物医学工程 生物医学工程
- 紧急医疗 紧急医疗
背景情况:
- 目前的静血粉末缺乏足够的组织粘附和血栓支持,导致血液冲洗.
- 需要先进的血液静止剂,提高有效性和安全性,以应急控制出血.
研究的目的:
- 开发和评估一种新型混合动力静血粉末 (QAL),该粉末由四分化奇托 (QCS),甲基醇修饰的酸 (Cat-SA) 和拉波尼特 (Lap) 组成.
- 评估QAL粉末的静血性能,组织粘附性,抗菌活性和生物相容性.
主要方法:
- 通过结合QCS,Cat-SA和Lap粉末,合成了一种混合粉末 (QAL).
- 通过测量血液凝形成,粘附强度,并将性能与Celox.com进行比较来评估静血疗效.
- 还评估了抗菌活性和细胞/血液生物相容性.
主要成果:
- QAL迅速将血液转化为一个强大的粘合凝,粘合强度为31.33 ± 1.56kPa.
- 与Celox相比,QAL表现出优越的静血性能.
- 粉末表现出显著的抗菌活性和与细胞和血液的良好生物相容性.
结论:
- 混合QAL粉提供强大的凝血,优秀的湿组织粘附性,抗菌性质和生物安全性.
- 它的易用性和稳定的存储使其成为紧急静血应用的有希望的候选者.
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