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三层溶解微针用于通过皮肤输送米诺西迪尔:一项概念验证研究

Nur Afika¹, Afifah Fadhilah Saniy¹, Athaullah Akmal Fawwaz Dharma¹

¹Faculty of Pharmacy, Hasanuddin University, Makassar, Indonesia.

Journal of biomaterials science. Polymer edition

|May 8, 2024

概括

与传统奶油相比,三层溶解微针有效地为脱发症提供氧化,增强皮肤透率并减少刺激.

科学领域:

皮肤病学皮肤病学
药品制造药品制造药品制造
纳米技术纳米技术

背景情况:

脱发症 (alopecia areata) 是一种导致脱发的自身免疫性疾病.
米诺西迪尔 (MNX) 是一种常见的治疗方法,但具有诸如低生物可用性和副作用等局限性.
现有的微针 (MN) 输送MNX显示透率降低和潜在的刺激.

研究的目的:

开发和评估三层溶解微针 (TDMN) 以提高MNX的透皮输送.
为了改善MNX的透,并减少发区治疗的局部副作用.

主要方法:

将MNX制成三层溶解微针 (TDMN).
物理化学评估,包括机械强度和角层透.
活体透和皮肤动力学研究比较TDMN与MNX奶油.
使用HET-CAM和血液溶解试验进行体外安全评估.

主要成果:

TDMN表现出足够的机械强度,可以穿透角层.
在TDMN2配方实现显著更高的体外透 (165.28μg/cm2) 比MNX奶油 (46.03μg/cm2).
活体和体内皮肤动力学研究表明,与奶油相比,TDMN2在皮肤中的残留药物度更高.
HET-CAM和血液溶解试验表明没有刺激或毒性的潜力.

结论:

三层溶解微针 (TDMN) 提供了一种有前途的方法,用于通过皮肤输送氧化.
TDMN有效地提高了MNX的皮肤透和保留,克服了传统配方的局限性.
这种新型的输送系统具有改善脱发区治疗的潜力,并减少副作用.

关键词:

这种药物是米诺西迪尔 (Minoxidil).微针微针是一种微针.通过皮肤传递的传递.三层溶解的微针

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