相关实验视频

Updated: May 5, 2026

Fabrication of High Contact-Density, Flat-Interface Nerve Electrodes for Recording and Stimulation Applications

Fabrication of High Contact-Density, Flat-Interface Nerve Electrodes for Recording and Stimulation Applications

Published on: October 4, 2016

灵活的环形生物电子技术可实现360度记录和脊髓刺激

Ben J Woodington¹, Jiang Lei², Alejandro Carnicer-Lombarte¹

¹Electrical Engineering Division, Department of Engineering, University of Cambridge, Cambridge, UK.

Science advances

|May 8, 2024

概括

灵活的电子产品为脊髓损伤 (SCI) 修复提供了新的希望. 这种新型设备可以同时记录和刺激,弥合完整的SCI,并显示出人类应用的潜力.

科学领域:

神经科学是一个神经科学.
生物医学工程生物医学工程
材料科学材料科学材料科学

背景情况:

脊髓损伤 (SCI) 会严重损害运动和感官功能.
目前对SCI的治疗方法在恢复神经功能方面存在局限性.
需要先进的神经接口来有效管理SCI.

研究的目的:

开发和评估用于周围脊髓接口的薄膜,灵活的电子设备.
为了使脊髓管道的同时记录和刺激.
证明SCI治疗中的临床转化潜力.

主要方法:

环形薄膜柔性电子产品是为脊髓接口而设计的.
该设备被测试为同时记录和刺激背部,侧面和腹部通道.
在体内研究是在麻醉和自由移动的动物中进行的.
使用尸体模型评估了人类应用潜力.

主要成果:

在老鼠中成功捕获和诱导运动和感官信号.
一个闭环系统的概念验证,以弥合完整的脊髓损伤.
在自由移动的动物中验证了设备的安全性.
通过尸体研究证明了人类应用的可行性.

结论:

薄膜柔性电子产品为脊髓接口提供了一个有前途的方法.
开发的设备可以同时记录和刺激神经活动,为SCI提供潜在的解决方案.
该技术显示出一条明确的临床应用路径,考虑安全植入和绳索完整性.

更多相关视频

Simultaneous Recordings of Cortical Local Field Potentials, Electrocardiogram, Electromyogram, and Breathing Rhythm from a Freely Moving Rat

Simultaneous Recordings of Cortical Local Field Potentials, Electrocardiogram, Electromyogram, and Breathing Rhythm from a Freely Moving Rat

Published on: April 2, 2018

The Muscle Cuff Regenerative Peripheral Nerve Interface for the Amplification of Intact Peripheral Nerve Signals

The Muscle Cuff Regenerative Peripheral Nerve Interface for the Amplification of Intact Peripheral Nerve Signals

Published on: January 13, 2022

相关概念视频

The Spinal Cord

The Spinal Cord

The spinal cord is the body’s major nerve tract of the central nervous system, communicating afferent sensory information from the periphery to the brain and efferent motor information from the brain to the body. The human spinal cord extends from the hole at the base of the skull, or foramen magnum, to the level of the first or second lumbar vertebra.

Spinal Cord

Spinal Cord

The spinal cord, a critical component of the central nervous system, extends from the base of the brainstem to the lumbar region of the vertebral column. It is essential for maintaining physical stability and facilitating communication between the brain and peripheral parts of the body.