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在治疗人类固体瘤的CAR细胞中,TOP CAR使用TMIGD2作为安全有效的辅助刺激域

Christopher D Nishimura1,2, Devin Corrigan1,2, Xiang Yu Zheng3

  • 1Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.

Science advances
|May 8, 2024
PubMed
概括

一种新的TMIGD2优化强效/持久性 (TOP) CAR-T疗法对固体瘤具有前景. 这种新的CAR-T方法增强了抗瘤活性和持久性,比现有治疗方法提供了潜在的进步.

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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