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Updated: Jun 26, 2025

Using the E1A Minigene Tool to Study mRNA Splicing Changes
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Using the E1A Minigene Tool to Study mRNA Splicing Changes

Published on: April 22, 2021

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一个可解释的模型,用于动物和植物基因的mRNA前拼接

Kayla McCue1,2, Christopher B Burge1,2

  • 1Computational and Systems Biology PhD Program, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

Science advances
|May 8, 2024
PubMed
概括

SMsplice通过整合拼接地点动图,监管元素和长度偏好,准确地预测各种物种的拼接地点. 这种模型揭示了保存和特定物种的拼接机制,突出了基因表达调节的进化差异.

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