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Updated: Jun 26, 2025

Separation of Single-stranded DNA, Double-stranded DNA and RNA from an Environmental Viral Community Using Hydroxyapatite Chromatography
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Separation of Single-stranded DNA, Double-stranded DNA and RNA from an Environmental Viral Community Using Hydroxyapatite Chromatography

Published on: September 29, 2011

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在生物相关的二碳酸盐缓冲体中药物晶体沉:与酸盐缓冲体进行了一项经过良好控制的比较研究

Hibiki Yamamoto1, Kiyohiko Sugano1

  • 1Molecular Pharmaceutics Laboratory, College of Pharmaceutical Sciences, Ritsumeikan University, 1-1-1, Noji-higashi, Kusatsu, Shiga 525-8577, Japan.

Molecular pharmaceutics
|May 8, 2024
PubMed
概括

药物沉率在二碳酸盐缓冲器 (BCB) 和酸盐缓冲器 (PPB) 之间有所不同. 可电离的弱酸和弱基在BCB中沉速度较慢,影响了药物配方研究.

关键词:
碳酸二氧化碳的使用方法生物相关的生物相关.毒品 毒品 毒品 是一种药物.在pKa pKa pKa降水 降水 降水 降水 降水

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Phosphate Buffer

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The titration of a polyprotic base such as sodium carbonate with a strong acid such as hydrochloric acid results in two equivalence points on the titration curve. At the first equivalence point, the carbonate ions in the base are completely converted to bicarbonate ions. The second equivalence point corresponds to the complete conversion of bicarbonate ions to carbonic acid, which dissociates into carbon dioxide and water. The region before the first equivalence point corresponds to the...
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Protein Buffers in Blood Plasma and Cells

The human body utilizes protein buffer systems to maintain a stable pH. These systems capitalize on the dual role of amino acids, which can act as acids or bases by accepting or releasing hydrogen ions in response to pH changes. Protein buffer systems are particularly significant in the extracellular fluid (ECF) and intracellular fluid (ICF) of active cells, where structural and functional proteins provide substantial buffering capacity.
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Buffer solutions do not have an unlimited capacity to keep the pH relatively constant . Instead, the ability of a buffer solution to resist changes in pH relies on the presence of appreciable amounts of its conjugate weak acid-base pair. When enough strong acid or base is added to substantially lower the concentration of either member of the buffer pair, the buffering action within the solution is compromised.
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Chemical buffers play a critical role in the body's regulation of pH levels. These systems contain one or more compounds that stabilize pH changes by neutralizing strong acids or bases. When pH levels drop, hydrogen ions bind to a weak base; when pH levels rise, hydrogen ions are released. This dynamic process helps maintain pH within a narrow and stable range essential for normal physiological function.
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