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通过细胞矩阵启发的生物模拟纳米载体向大脑提供蛋白质疗法

Jialin Huang^1,2, Yuli Fu¹, Antian Wang¹

¹Department of Pharmacology and Chemical Biology, Shanghai Universities Collaborative Innovation Center for Translational Medicine, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.

Advanced materials (Deerfield Beach, Fla.)

|May 8, 2024

概括

一种新的仿生纳米载体有效地通过中枢神经系统疾病的血脑屏障传递蛋白质治疗药物. 这一突破改善了小鼠创伤性脑损伤和肌缩性侧面硬化症的治疗方法.

科学领域:

生物医学工程生物医学工程
神经科学是一个神经科学.
药物运输药物运输药物运输

背景情况:

蛋白质疗法对中枢神经系统 (CNS) 疾病有前途.
血脑屏障 (BBB) 显著限制了蛋白质药物向大脑的输送.
现有的输送方法在达到细胞内中枢神经系统的目标方面面临挑战.

研究的目的:

开发一种新的仿生纳米载体,以便在BBB中有效地输送蛋白质.
在中枢神经系统疾病的临床前模型中研究这种纳米载体的疗效.
克服中枢神经系统疾病用蛋白质疗法治疗的局限性.

主要方法:

蛋白质与氨酸 (HA) 和质氨酸 (PRTM) 自组合,形成核心.
将带有蛋白质的核心纳入ApoE3重建的高密度脂蛋白 (rHDL).
在创伤性脑损伤 (TBI) 和肌缩性侧面硬化症 (ALS) 鼠标模型中对纳米载体 (蛋白质-HA-PRTM-rHDL) 的评估.

主要成果:

纳米载体成功地促进了蛋白质穿透BBB和细胞内输送.
载有catalase的纳米载体 (CAT-HA-PRTM-rHDL) 在TBI小鼠中改善了空间学习和记忆.
在ALS模型小鼠中观察到增强的运动功能和延长的生存时间.

结论:

灵感来自细胞矩阵的纳米平台能够有效地向中枢神经系统输送蛋白质治疗药物.
这种方法为治疗中枢神经系统疾病 (如TBI和ALS) 提供了一个新的策略.
生物模拟纳米载体在神经系统疾病中显示出显著的治疗潜力.

关键词:

生物仿真纳米载体纳米载体血脑屏障血脑屏障血脑屏障血脑屏障中枢神经系统中枢神经系统细胞内输送是细胞内输送.蛋白质治疗药物蛋白质治疗药物

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