在精神分裂症,未受影响的第一级亲属和健康对照中,不匹配的消极性
Anushree Bose1, Sri Mahavir Agarwal1, Hema Nawani1
1WISER Neuromodulation Program, Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bangalore, India.
Journal of psychiatric research
|May 8, 2024
概括
持续不匹配负面性 (MMN) 是精神分裂症患者预测错误信号缺陷的强有力的指标. 由MMN捕获的听觉感官处理反映了动态的认知功能,而不是持久的症状.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 认知科学 认知科学
背景情况:
- 不匹配负面性 (MMN) 幅度在精神分裂症 (SZ) 中减弱.
- 关于SZ中的MMN存在不一致的发现,原因是样本的变化和刺激类型.
- 在SZ患者未受影响的第一级亲属 (FDR) 中,MMN与精神分裂症的联系尚未得到充分研究.
研究的目的:
- 系统地检查未使用药物SZ (dSZ),慢性SZ (cSZ),FDR和健康对照 (HC) 的MMN.
- 调查在FDR中的精神分裂性得分和MMN指数之间的相关性.
- 为了确定持续时间MMN或频率MMN是否是更可靠的SZ相关赤字指标.
主要方法:
- 使用了一种双色的被动听觉奇怪MMN范式,具有持续偏差和频率偏差的条件.
- 在dSZ (n=22),cSZ (n=30),FDR (n=36) 和HC (n=32) 之间的MMN指数进行比较.
- 在FDR组中,与MMN指数相关联的精神分裂症得分与MMN指数相关联.
主要成果:
- 与对照组相比,在dSZ和cSZ组中,持续时间-MMN振幅显著减弱.
- 在dSZ和cSZ之间没有发现MMN指数的显著差异.
- 在SZ患者中,MMN指数与精神病理学分数或疾病特征没有相关性.
- 划分型特征的测量与FDR的MMN指数没有相关性.
结论:
- 持续时间-MMN是预测误差信号缺陷在精神分裂症更敏感的标志物.
- 频率-MMN振幅在各组之间没有显著差异.
- MMN指数与持久的精神分裂症相关的精神病理学没有相关性,这表明MMN反映了暂时的认知状态.
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