解开阿尔卑斯山灰牛的内生模式和选择信号
G Gomez Proto1, E Mancin1, C Sartori1
1Department of Agronomy, Food, Natural Resources, Animals and Environmet, University of Padua, Viale dell'Università, 16, 35020 Legnaro, Italy.
概括
基因组数据显示,阿尔卑斯灰牛中古代的近亲繁殖很普遍,同胞性 (ROH) 突出选择信号和疾病抵抗力和生育能力的基因. 这项研究提高了对品种遗传多样性的理解.
科学领域:
- 动物遗传学动物遗传学
- 人口遗传学 人口遗传学
- 畜牧养殖 畜牧养殖 畜牧养殖
背景情况:
- 亲生繁殖对牲畜的遗传多样性和特征产生重大影响.
- 基因组数据提供了超越传统血统分析的先进见解.
- 了解近亲繁殖对于管理当地的牛品种至关重要.
研究的目的:
- 用血统和基因组方法评估阿尔卑斯灰牛的近亲繁殖水平.
- 通过 homozygosity (ROH) 运行来分析古代和最近的近亲繁殖模式.
- 在ROH群岛内识别选择信号和相关基因.
主要方法:
- 用INBUPGF90分析亲生关系系数的亲生关系数据 (165,575个人).
- 使用PLINK v1.9和DetectRUNS R包分析的基因组数据 (1,180个人).
- 确定了同胞性 (ROH) 的运行,以精确确定基因组区域和选择压力.
主要成果:
- 在血统和基因组亲生繁殖系数之间观察到适度的相关性.
- 古代的近亲繁殖很普遍 (>90%的ROHs<8Mb),与国际品种相比,最近的近亲繁殖较低.
- 染色体6和7上的两个主要的ROH岛屿含有与免疫力,抗病能力和生育能力相关的基因.
结论:
- 基因组分析,特别是ROH,在评估品种遗传多样性时克服了血统限制.
- 古代的近亲繁殖有着显著的遗传影响,而ROH岛屿表明阿尔卑斯山灰牛的选择性扫除.
- 这些发现为本地品种的遗传特征和历史变化提供了关键的见解.
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