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在淡水生物中的乙克洛维尔生态基因毒性
Roberta Nugnes1, Chiara Russo1, Angela Di Matteo1
1Department of Environmental, Biological and Pharmaceutical Sciences and Technologies, University of Campania "Luigi Vanvitelli", Via Vivaldi 43, Caserta 81100, Italy.
Ecotoxicology and environmental safety
|May 8, 2024
概括
即使在较低的环境度下,阿西克洛维尔 (ACV) 对水生生物,特别是Ceriodaphnia dubia构成慢性毒性风险. 进一步评估对于保护水生生态系统至关重要.
科学领域:
- 环境毒理学环境毒理学
- 生态毒理学 生态毒理学
- 水生生态学 水生生态学
背景情况:
- 越来越多地在地表水中检测到阿西克洛维尔 (ACV),需要评估其对环境的影响.
- ACV是一种广泛使用的抗病毒药物,对水生生物有潜在的非向作用.
研究的目的:
- 研究Acyclovir对关键的淡水非标生物的生态遗传毒性影响.
- 评估ACV在水生物种中的急性和慢性毒性和基因毒性.
主要方法:
- 暴露于Raphidocelis subcapitata,Brachionus calyciflorus,Ceriodaphnia dubia和Heterocypris的暴露与阿西克洛维尔不符.
- 评估急性和慢性毒性,包括生殖效应.
- 在Ceriodaphnia dubia中评估DNA链断裂和活性氧物种.
主要成果:
- 在Ceriodaphnia dubia中观察到环境相关度 (EC50 = 0.03μg/L) 的慢性毒性.
- 基因毒性通过DNA链断裂和Ceriodaphnia dubia中的ROS在 >200μg/L的度下表明.
- 在环境相关水平的Brachionus calyciflorus和Ceriodaphnia dubia的繁殖抑制.
结论:
- 阿西克洛维尔对水生生态系统具有显著的慢性和遗传毒性风险.
- 风险系数超过临界值,表明对水生生物的潜在危害.
- 迫切需要在水生环境中对acyclovir进行全面的风险评估.
关键词:
藻类藻类是一种藻类.造成的DNA损伤是DNA损伤.达夫尼德斯 (Daphnids) 是一个类动物.乌鱼是什么意思?乌鱼是什么意思?风险评估 风险评估 风险评估罗蒂费尔斯 (Rotifers) 是一种生态动物.更多相关视频
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