早期青春期和GnRH类似物:美国儿科内分泌学家当前的治疗实践和前景
Emily Breidbart1, Jeniece Ilkowitz1, Molly O Regelmann2
1Division of Pediatric Endocrinology and Diabetes, NYU School of Medicine, New York, New York, USA.
Hormone research in paediatrics
|May 8, 2024
概括
儿科内分泌学家更熟悉较旧的激素释放激素模拟 (GnRHa) 配方,比较新的选择更频繁地开处方. 关于治疗疗效和监测早期青春期的知识缺口和不一致的做法存在.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 药理学 药理学是指药理学的学科.
- 临床实践指南 临床实践指南
背景情况:
- 淋巴激素释放激素类似物 (GnRHas) 是早期青春期的标准治疗方法.
- 近年来,已经批准了几种新的GnRHa配方,扩大了治疗选择.
研究的目的:
- 评估美国儿科内分泌学家当前的治疗环境,处方行为和与GnRHas相关的做法.
- 识别知识缺口和改善早期青春期管理的领域.
主要方法:
- 一项调查分发给美国的儿科内分泌学家.
- 该调查涵盖了临床实践,GnRHa配方的知识,中心早期青春期 (CPP) 治疗实践和医疗保健资源利用情况.
- 223名调查受访者提供了他们熟悉,偏好和处方模式的数据.
主要成果:
- 实践者与较旧,更短作用的GnRHas (例如,3个月制备) 相比,更熟悉较旧,更长效的GnRHas (例如,6个月的普罗利德).
- 家庭偏好和保险覆盖率显著影响了GnRHa的选择,在治疗疗效评估和中枢神经系统成像方面注意到不一致的做法.
- 很大一部分受访者对成人配方和成本差异缺乏熟悉.
结论:
- 对GnRHas的熟悉性对于较旧,短效的配方来说更大,这些配方更频繁地被处方.
- 在CPP的诊断成像和实验室监测方面缺乏共识,保险要求有显著的变化.
- 需要进一步的研究,以制定基于证据的指导方针,GnRHa用于儿科内分泌学,解决不同的配方的成本和安全问题.
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