从多中心的角度来看,雌激醇和孕激素药物的可用性,使用和偏好用于诱导青春期
Aneta M Gawlik-Starzyk1, Małgorzata Więcek2, Debbie Matthews3
1Department of Pediatrics and Pediatric Endocrinology, School of Medicine in Katowice, Medical University of Silesia, Katowice, Poland.
Hormone research in paediatrics
|May 8, 2024
概括
全球获得低剂量激素疗法用于女性青春期诱导是具有挑战性的. 许多国家缺乏适当的低剂量17β-雌激醇片和贴片,阻碍了治疗.
科学领域:
- 内分泌学 在内分泌学.
- 儿科内分泌学 儿科内分泌学
- 生殖健康 生殖健康
背景情况:
- 天然雌激素 (17β-雌激醇) 对于患有阴道腺的女孩的青春期诱导至关重要.
- 目前全球可用的适合低剂量口服或通过皮肤注射的激素配方是不一致的.
- 这项研究解决了全世界需要可访问的激素制剂的需求.
研究的目的:
- 评估口服和透皮17β-雌激醇和孕激素制剂的全球可用性.
- 确定获得适合女性青春期诱导的激素配方所面临的挑战.
- 为指导方针提供信息,并改善必要激素治疗的可获得性.
主要方法:
- 一项由ESPE特纳综合征工作组认可的调查问卷研究.
- 在全球范围内通过SurveyMonkey和直接推广 (2020年6月 - 2022年12月) 针对儿科内分泌学家.
- 收集了关于口服/透皮17β-雌激醇和孕激素制剂可获得性的数据.
主要成果:
- 来自45个国家的229名医疗保健专业人员参加了会议.
- 成人剂量口服/通过皮肤17β-雌激醇是广泛可用的,通过皮肤更喜欢.
- 低剂量17β-雌激醇片 (0.5毫克) 和贴片 (14-25微克/天) 在许多地区的可用性有限.
- 口服孕激素是广泛可用的,并优先于通过皮肤的途径.
结论:
- 在获得适合女性青春期诱导的激素制剂方面,全球存在显著的差异.
- 最低可用的雌激素剂量通常为50μg (贴片) 和2mg (片).
- 改善低剂量17β-雌激醇的可获得性,特别是药片,对于解决全球健康不平等至关重要.
关键词:
可用性可用性可用性激素替代疗法是一种激素替代疗法.催产素缺陷症是什么 催产素缺陷症雌激素是一种雌激素.孕激素 (Progesterone) 是一种激素.诱导青春期的诱导图纳综合征是特纳综合征的一种症状.更多相关视频
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