潜在的治愈性肺癌患者接受手术的呼气分析:一项纵向研究
Jonas Herth1, Felix Schmidt2,1, Sarah Basler2,1
1Department of Pulmonology, University Hospital Zurich, 8091 Zurich, Switzerland.
Journal of breath research
|May 8, 2024
概括
呼气分析显示,通过识别挥发性有机化合物,有可能检测肺癌. 手术后呼吸模式的变化凸显了它对查和诊断的有用性.
科学领域:
- 生物化学 生物化学
- 在瘤学瘤学.
- 分析化学 分析化学
背景情况:
- 肺癌的诊断依赖于侵入性方法.
- 早期检测对于改善患者结果至关重要.
- 呼气分析提供了一个非侵入性的诊断方法.
研究的目的:
- 调查呼气分析用于肺癌检测的潜力.
- 在肺癌患者中识别挥发性有机化合物 (VOC) 生物标志物.
- 为了评估手术前后呼吸模式的变化.
主要方法:
- 对29名未接受过治疗的肺癌患者进行了长度研究.
- 使用二次电喷离子化高分辨率质谱分析.
- 在手术前和手术后识别具有显著差异的VOCs (log2倍变化≥1,q值≥0.71).
主要成果:
- 检测到3482个VOC特征,515个显示出明显的手术前和手术后的差异.
- 发现了潜在的生物标志物:3-氧特特拉迪卡诺酸 (m/z-242.18428) 和印 (m/z-117.0539).
- 主要组件分析表明了不同的集群,包括最初错过的复发性肺癌病例.
结论:
- 呼气分析可以检测肺癌并监测治疗反应.
- 手术后呼吸模式的变化强调了该方法的诊断潜力.
- 这种非侵入性技术对肺癌查和早期检测有前途.
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