病理健康焦虑的机制研究:系统性审查和新兴的概念框架
Andrew J Guthrie1, Sara Paredes-Echeverri1, Cristina Bleier1
1Functional Neurological Disorder Unit, Division of Behavioral Neurology and Integrated Brain Medicine, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Journal of affective disorders
|May 8, 2024
概括
病理性健康焦虑 (PHA) 涉及认知和情感偏见,早期有改变整体感知的证据. 对这些机制的进一步研究对于开发更好的治疗方法至关重要.
科学领域:
- 精神病学是一个精神病学.
- 神经科学是一个神经科学.
- 心理学 心理学 心理学
背景情况:
- 病理性健康焦虑 (PHA),包括下症和疾病焦虑障碍,在医疗机构中很普遍.
- PHA与显著的医疗保健成本有关.
- PHA的潜在心理和神经生物学机制尚未完全理解.
研究的目的:
- 系统地审查和描述病态健康焦虑 (PHA) 的机制性理解.
- 确定涉及PHA的认知,行为,情感和神经生物学因素.
主要方法:
- 对1990年至2022年间发表的文章进行系统审查.
- 在PubMed,PsycINFO和Embase数据库中进行了搜索.
- 包括的研究使用了PHA患者的行为任务和/或生理测量.
主要成果:
- 57项研究符合纳入标准,质量变化不稳定,往往质量不足.
- 调查结果涉及注意力和记忆偏差,狭窄的健康概念,威胁确认,安全行为和有偏见的情感处理.
- 最初的证据表明,PHA中过度估计了整感受性刺激.
- 在PHA中神经内分泌,电生理学和脑成像研究仍处于早期阶段.
结论:
- 当前的研究往往对PHA进行了断然的处理,忽视了维度方面.
- 理论化的机制包括次优健康概念,改变的整体感知建模,偏见的预测和异常的预测错误学习.
- 对PHA病理生理学的进一步研究可能会产生诊断生物标志物,并为新的治疗提供信息.
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