相关实验视频

Updated: May 3, 2026

Antigenic Liposomes for Generation of Disease-specific Antibodies

Antigenic Liposomes for Generation of Disease-specific Antibodies

Published on: October 25, 2018

用于诊断聚乙烯糖醇过敏的PEG化脂质体

Griffith B Perkins¹, Matthew J Tunbridge², Plinio R Hurtado²

¹Adelaide Medical School, University of Adelaide, Adelaide, Australia; Central and Northern Adelaide Renal and Transplantation Service, Royal Adelaide Hospital, Adelaide, Australia; Immunology Directorate, SA Pathology, Adelaide, Australia.

The Journal of allergy and clinical immunology

|May 8, 2024

概括

诊断聚乙烯糖醇 (PEG) 过敏是一个挑战. 与传统方法相比,使用PEGylated脂质纳米粒子疫苗和药物的测试可以提高PEG过敏的诊断准确度.

科学领域:

免疫学免疫学免疫学
过敏和免疫学过敏和免疫学
药理学药理学是指药理学的学科.

背景情况:

聚乙烯甘醇 (PEG) 是药物和疫苗中常见的辅助剂.
PEG过敏可以引起过敏反应,但由于当前皮肤测试的表现不佳,诊断很难.
在临床实践中,PEGylated脂质体配方越来越多地使用.

研究的目的:

评估用于诊断PEG过敏的PEG化脂类药物的诊断性能.
为了比较PEGylated脂类药物的疗效与PEG过敏现有的诊断测试.

主要方法:

在9名患有PEG过敏史的患者身上进行皮肤测试,使用含有PEG的药物和PEG化脂质纳米粒子疫苗 (BNT162b2).
评估了基因细胞对未结合和脂质体PEG的ex vivo反应性.
对PEGylated脂质体的基因细胞反应的特异性使用竞争性抑制试验进行了研究.

主要成果:

只有22%的患有PEG过敏史的患者在传统皮肤测试中呈阳性.
所有患者都在皮肤或基因细胞激活测试中呈阳性,使用PEGylated脂质体BNT162b2疫苗.
在过敏患者中,PEG化脂质体药物激活了ex vivo基细胞,与纯化的PEG2000不同.

结论:

在脂质纳米颗粒上呈现PEG可增强其过敏性.
基化脂质纳米粒子疫苗和药物改善了对PEG过敏的诊断.
这种方法提供了一种更可靠的方法来识别PEG过敏.

关键词:

BNT162b2b2 在线阅读在 COVID-19 疫情中,对于PEG过敏的过敏过敏的诊断过敏的诊断基细胞激活的激活脂质纳米颗粒是一种纳米粒子.脂质体组是什么? 脂质体组是什么?这是mRNA疫苗.聚乙烯糖醇是一种聚乙烯糖醇.接种疫苗接种疫苗

更多相关视频

Detection of Endotoxin in Nano-formulations Using Limulus Amoebocyte Lysate LAL Assays

Detection of Endotoxin in Nano-formulations Using Limulus Amoebocyte Lysate LAL Assays

Published on: January 30, 2019

Validation of Therapeutic Agent Conjugation to Polyvinyl Alcohol-Coated Medical Devices

Validation of Therapeutic Agent Conjugation to Polyvinyl Alcohol-Coated Medical Devices

Published on: November 29, 2024

相关概念视频

Oligosaccharide Assembly

Oligosaccharide Assembly

Protein glycosylation starts in the ER lumen and continues in the Golgi apparatus. Glycosyltransferases catalyze the addition of sugar molecules or glycosylation of proteins. Usually, these enzymes add sugars to the hydroxyl groups of selected serine or threonine residues to form O-linked glycans or the amino groups of asparagine residues to form N-linked glycans. Different positions on the same polypeptide chain can contain differently linked glycans.
Multiple sugar molecules that may or may...

Radiological Investigation III: Pulmonary Angiogram and PET Scan

Radiological Investigation III: Pulmonary Angiogram and PET Scan

Radiological investigations are paramount in the diagnosis and management of various pulmonary diseases. Two essential investigations are the Pulmonary Angiogram and the Positron Emission Tomography (PET) Scan.
Pulmonary Angiogram
A Pulmonary Angiogram is an invasive procedure involving injecting a contrast medium through a catheter threaded into the pulmonary artery or the right side of the heart to visualize the pulmonary vasculature. Computed Tomography (CT) scans have mainly replaced this...

Hyperglycemia

Hyperglycemia

Hyperglycemia is an abnormally high blood glucose level. It is diagnosed by fasting glucose ≥126 mg/dL, 2-hour oral glucose tolerance test (or OGTT) ≥200 mg/dL, random glucose ≥200 mg/dL with symptoms, or HbA1c ≥6.5%. However, HbA1c results may be unreliable in certain conditions, such as anemia or hemoglobinopathies, and the diagnosis should be confirmed unless classic symptoms are present. Postprandial hyperglycemia is typically considered significant when glucose...