可访问的方法和工具来估计人类的化学物质暴露,以支持风险评估:系统的范围审查
Maria E Kalyva1, Gunn E Vist2, Michael Guy Diemar3
1Norwegian Institute of Public Health, Division of Climate and Environmental Health, Oslo, Norway.
Environmental pollution (Barking, Essex : 1987)
|May 8, 2024
概括
人类暴露评估方法和计算工具对于环境健康风险评估至关重要. 这次审查确定了63个模型,突出了化学安全评估中概率分析和AI的趋势.
科学领域:
- 环境健康科学 环境健康科学
- 毒理学 毒理学 毒理学
- 计算化学计算化学
背景情况:
- 暴露评估对于了解环境健康研究中的化学风险至关重要.
- 准确的暴露数据对于有效的风险评估和监管决策至关重要.
- 计算方法的进步越来越多地支持对人类暴露的评估.
研究的目的:
- 系统地审查可访问的人类暴露评估方法和计算工具.
- 识别趋势并评估这些方法和工具对各种化学品类和暴露路径的有用性.
- 为在化学风险评估中选择适当的方法和工具提供指导,特别是在ONTOX项目中.
主要方法:
- 使用Sysrev平台进行了系统范围审查,将机器学习纳入效率和准确性.
- 过的出版物是2000年以后出版的出版物,详细描述了暴露评估方法.
- 根据其使用频率,相关化学类,暴露途径和输入参数,分析了已识别的数学模型和工具箱.
主要成果:
- 暴露评估方法适用于各种化学品类别,包括农药,金属和挥发性有机化合物.
- 自2000年以来,使用概率分析和计算方法来计算人类暴露的使用显著增加.
- 在全球范围内确定了63个数学模型和工具箱,其中12个显示频繁使用和与暴露特征的特定关联.
结论:
- 已识别的模型和工具可以指导在化学安全评估中选择适合人类暴露评估的方法.
- 了解这些模型的输入参数对于协调暴露评估方法至关重要.
- 这项工作支持监管过程的一致性,并推进下一代风险评估策略,包括人工智能驱动的毒性测试.
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