在奖励和厌恶中介质质体:从细胞异质性到行为
Ricardo Bastos-Gonçalves1, Bárbara Coimbra1, Ana João Rodrigues1
1Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal; ICVS/3B's-PT Government Associate Laboratory, Braga/Guimarães, Portugal.
介质体,包括脚体体 (PPN) 和后背体 (LDT),在激发行为中起着关键作用. 这篇评论强调了它们在奖励和厌恶电路上的被忽视的影响.
科学领域:
- 神经科学是一个神经科学.
- 行为神经科学 行为神经科学
背景情况:
- 介质体由脚体体 (PPN) 和后背体 (LDT) 组成,与基底,运动和边缘系统有广泛的连接.
- 这些结构的战略定位是调节动机行为,但它们在奖励和厌恶电路中的作用仍然被低估.
研究的目的:
- 提供关于PPN和LDT对运动,边缘和基底腺系统的连接性和影响的全面审查.
- 巩固目前关于PPN和LDT在动机行为中的作用的研究,特别是奖励和厌恶.
主要方法:
- 使用病变,药理学和光遗传/化学遗传方法进行的开创性研究的审查.
- 对奖励和厌恶的神经回路的现有文献进行分析.
主要成果:
- 来自各种方法的证据表明PPN和LDT在调节奖励和厌恶行为的关键作用.
- PPN和LDT对参与动机行动的目标系统产生重大影响.
结论:
- PPN和LDT是激发行为背后的神经回路的关键,但经常被忽视的组成部分.
- 对PPN和LDT细胞机制的进一步研究是必要的,以充分理解它们对行为和神经精神疾病的贡献.
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