从Sarcandra glabra残留物中提取的多糖因调节糖尿病小鼠肠道微生物群而减轻认知障碍
Meng Ye1, Yameng Liu1, Feng Wang2
1Jiangsu Key Laboratory of Druggability of Biopharmaceuticals, State Key Laboratory of Natural Medicines, School of Life Science and Technology, China Pharmaceutical University, Nanjing 210009, PR China.
概括
萨坎德拉白多糖 (SERP) 显示出治疗糖尿病脑病变 (DE) 的前景. 它通过调节肠道微生物群和增强黄油酸来改善认知功能,为DE提供了一种新的治疗方法.
科学领域:
- 神经科学是一个神经科学.
- 代谢障碍 代谢障碍 代谢障碍
- 微生物学 微生物学
背景情况:
- 糖尿病脑病变 (DE) 导致认知障碍,没有特定的治疗方法.
- 萨坎德拉白提取的残留多糖化物 (SERP) 已经证明了低血糖效应.
- 对于DE,SERP的治疗潜力仍然未被探索.
研究的目的:
- 研究SERP对糖尿病脑病变 (DE) 的治疗效果.
- 阐明SERP在德语中的作用的基本机制.
主要方法:
- 研究了SERP对葡萄糖和脂质代谢以及认知功能的影响.
- 分析了SERP对肠道微生物群组成和短链脂肪酸生产的影响.
- 评估了肠道屏障和神经回路的恢复.
主要成果:
- 在DE模型中,SERP改善了认知功能,并调节了葡萄糖/脂质代谢.
- 在肠道微生物群中,SERP丰富了Bacteroidales S24-7,增加了肠道黄油酸.
- SERP调节了肠内分泌细胞脂质代谢,修复了肠道屏障和神经回路.
结论:
- 通过调节肠道微生物群-肠道-大脑轴,SERP证明了对DE的治疗疗效.
- SERP的机制包括增强黄油酸的生产和恢复肠道完整性.
- SERP提出了一种潜在的新药候选药物用于治疗糖尿病脑病变.
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