6至12周龄婴儿的环境暴露:婴儿养和早期发育 (IFED) 研究
Mandy Goldberg1, Margaret A Adgent2, Danielle R Stevens1
1Epidemiology Branch, National Institute of Environmental Health Sciences, Durham, NC, USA.
Environmental research
|May 8, 2024
概括
婴儿暴露于,包括和BPA,在美国很普遍,婴儿的含量高于儿童,强调需要生物监测和来源调查.
科学领域:
- 环境健康 环境健康
- 内分泌学 在内分泌学.
- 儿科 儿科 儿科
背景情况:
- 类是消费品中发现的内分泌干扰化学物质.
- 婴儿暴露数据有限,但婴儿对内分泌干扰高度敏感.
- 这项研究评估了美国婴儿的水平和预测因素.
研究的目的:
- 描述了美国婴儿尿度的分布.
- 在6-12周的婴儿中确定暴露的预测因素.
- 为了比较婴儿的含量与老年儿童的含量.
主要方法:
- 对199名婴儿 (2010-2013) 的前性队列研究 (婴儿养和早期发育 - IFED).
- 在6周,8周和12周收集的尿样中测量了7种.
- 使用线性混合模型分析与母亲,社会人口和婴儿因素的关联.
主要成果:
- 检测到甲基帕拉本,基帕拉本和基-3的高中度.
- 婴儿甲基帕拉本水平比美国儿童高10倍;基帕拉本水平比美国儿童高3-4倍.
- 黑人母亲的婴儿有较高的BPA,和二;较低的三和三.
- 哺乳期婴儿的 triclosan 含量较高;母亲教育水平较低与 triclosan 含量较低有关.
- 夏季样本中的醇度更高.
结论:
- 在美国的婴儿中,广泛接触环境,特别是 parabens.
- 婴儿的度明显超过了老年儿童的度.
- 对婴儿和幼儿进行扩展的生物监测至关重要.
- 需要对暴露源进行进一步的研究,以尽量减少敏感发育时期的风险.
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