高血糖和中心肥胖症扰乱条件疼痛调节:一个单盲交叉随机对照试验
Di Ye1, Timothy J Fairchild2, Lechi Vo1
1School of Psychology and Centre for Healthy Ageing, College of Health and Education, Murdoch University, Murdoch, Western Australia, Australia.
The journal of pain
|May 8, 2024
概括
摄入葡萄糖会影响疼痛调节,特别是在中心肥胖症中. 控制血糖和身体脂肪可能有助于保持疼痛调节,可能减少糖尿病疼痛.
科学领域:
- 神经科学是一个神经科学.
- 内分泌学 在内分泌学.
- 疼痛研究 疼痛研究
背景情况:
- 高血糖和高脂肪是糖尿病患者疼痛的已知的危险因素.
- 了解葡萄糖代谢,身体脂肪分布和疼痛感知之间的相互作用对于开发有针对性的干预措施至关重要.
研究的目的:
- 研究急性摄入葡萄糖对疼痛敏感性,条件疼痛调节和自主功能在不同脂肪和血糖水平的个体的影响.
- 确定中心肥胖对葡萄糖负载和疼痛调节之间的关系的影响.
主要方法:
- 一项交叉研究设计,涉及64名没有疼痛的参与者,具有正常脂肪,高脂肪或高脂肪和高HbA1c的组合.
- 参与者摄入葡萄糖或与口味相匹配的糖对照剂,评估包括感官检测,疼痛值,条件疼痛调节和自主功能.
- 双能量X射线吸收度和腰部/部比率被用于评估脂肪和中心肥胖.
主要成果:
- 摄入葡萄糖显著削弱了所有参与者的压力疼痛抑制,这种效应因腰部/部比率较高而加剧.
- 患有HbA1c升高的个体表现出缺失热痛调节,并在葡萄糖负载后增加疼痛.
- 摄入葡萄糖会扰乱副交感活动,但不会影响内皮功能或其他感觉模式.
结论:
- 急性摄入葡萄糖会干扰内源性疼痛调节机制,特别是在存在中央肥胖症时.
- 过高血糖对疼痛调节的有害影响被中心肥胖症放大,可能导致糖尿病疼痛的发展.
- 控制血糖水平和体脂质量可能是维持疼痛调节能力和预防风险人群疼痛的关键.
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