在多种不同癌症中,nectin-4表达的转化PET成像与Ga-N188的68不同
Jianhua Zhang1, Xiaojiang Duan1, Xueqi Chen1
1Department of Nuclear Medicine, Peking University First Hospital, Beijing, China.
概括
使用68Ga-N188的正子发射断层扫描 (PET) 成像可以在各种癌症中非侵入性量化nectin-4表达. 这种方法有望指导患者选择用于像恩福图马布韦多丁 (enfortumab vedotin) 这样的nectin-4向疗法.
科学领域:
- 在瘤学瘤学.
- 核医学就是核医学.
- 分子成像学分子成像学
背景情况:
- 结核素细胞粘附分子4 (结核素-4) 在许多癌症中过度表达,导致瘤发生和转移.
- 恩福图马布维多丁 (Enfortumab vedotin) 是一种向素-4的药物,已被批准用于泌尿管癌,但其在其他癌症中的使用需要调查.
研究的目的:
- 评估使用68Ga-N188.8.的nectin-4向PET成像的可行性.
- 在多种瘤类型中非侵入性地量化膜性 nektin-4 表达.
- 探索其在针对性治疗的患者分层中的实用性.
主要方法:
- 六十二名患有16种癌症类型的患者同时接受68Ga-N188和18F-FDG PET/CT扫描.
- 免疫组织化学被用来将PET成像发现与36名患者的实际nectin-4表达相关联.
主要成果:
- 68Ga-N188 PET/CT SUVmax与膜性 nektin-4 表达呈正相关性 (r=0.458,P=0.005).
- 68Ga-N188和18F-FDG PET/CT的检测率相似 (95%与93.3%对比).
- 68Ga-N188显示出检测残留/复发性胰腺癌的潜力.
结论:
- 68Ga-N188 PET成像准确地反映了膜性 nektin-4表达,支持其在选择患者接受 nektin-4向治疗时的使用.
- 这种成像方法可能有助于探索在不同癌症中使用nectin-4向治疗的方法.
- 需要进一步的前性研究来证实68Ga-N188在胰腺癌重置阶段中的作用.
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