衰老对区域性体微观结构的差异性影响以及脉冲压的改变影响
Jessica N Kraft1, Stephanie Matijevic2,3, David A Hoagey2
1Center for Vital Longevity, Department of Psychology, School of Behavioral and Brain Sciences, The University of Texas at Dallas, Dallas, Texas 75235 Jessica.kraft@utdallas.edu.
eNeuro
|May 8, 2024
概括
衰老会不均地影响体,脉压加剧这种下降. 动脉硬会加剧与年龄相关的白质变化,影响整个生命周期的大脑微观结构.
科学领域:
- 神经科学是一个神经科学.
- 衰老研究研究 衰老研究
- 心血管健康 心血管健康
背景情况:
- 体对半球间通信至关重要,有不同的子区域.
- 衰老可能会对这些子区域产生不同的影响,可能受到心血管健康的影响.
- 心血管风险因素可能会损害白质的完整性.
研究的目的:
- 为了研究大脑体中衰老脆弱性的前后垂直梯度.
- 为了检查心血管健康,特别是脉冲压如何改变这种衰老模式.
- 为了评估与年龄相关的微观结构变化在callosal亚区域.
主要方法:
- 扩散权重成像和确定性通道图谱被用于分析状骨微观结构.
- 分数异构性 (FA),辐射扩散性 (RD) 和轴向扩散性 (AD) 来自五个角质子区域.
- 一般线性模型评估了174名健康成年人的年龄,高血压和脉压的影响.
主要成果:
- 没有发现高血压诊断对骨微观结构有显著影响.
- 高龄和高脉压与减少FA和增加RD/AD有关,表明微观结构较差.
- 与年龄相关的恶化跟随着前后斜坡,通过考虑脉冲压力来取消.
结论:
- 体中与年龄相关的白质恶化在区域上是可变的.
- 脉压是动脉硬的标志物,显著加剧了与年龄相关的微观结构变化.
- 心血管健康在调节大脑衰老模式方面发挥着至关重要的作用.
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