461,183名健康个体的肺功能障碍和肺癌风险:一个队列研究
Thu Win Kyaw1, Min-Kuang Tsai1, Chi Pang Wen2
1Global Health and Health Security Program, School of Public Health, Taipei Medical University College of Public Health and Nutrition, Taipei, Taiwan.
BMJ open respiratory research
|May 8, 2024
概括
肺功能受损,包括保持比率受损螺旋计 (PRISm) 和空气流阻塞 (AO),增加肺癌发病率和死亡风险,无论是一般人群还是从未吸烟的人群. 肺功能检测可以帮助肺癌查.
科学领域:
- 肺部医学 肺部医学
- 在瘤学瘤学.
- 流行病学 流行病学
背景情况:
- 肺功能受损与肺癌有关,但保留比率受损螺旋计 (PRISm) 和空气流阻塞 (AO) 的具体影响尚未完全理解.
- 这些特定的肺功能障碍与一般和从未吸烟的人群中的肺癌风险之间的关系需要进一步研究.
研究的目的:
- 调查不同类型的肺功能障碍 (PRISm和AO) 与肺癌发病率和死亡率的风险之间的联系.
- 分析一般人群和一组从未吸烟的人群中的这些风险.
主要方法:
- 在1994年1月1日至2017年12月31日期间,使用台湾健康监测计划的数据进行了一项回顾性队列研究.
- 参与者接受了基线螺旋计,PRISm定义为FEV1/FVC比率>0.7和FEV1<0.8,AO定义为FEV1/FVC比率<0.7.7.
- 考克斯的比例危险模型和立方斜线曲线被用来评估肺功能障碍与肺癌风险之间的关联.
主要成果:
- 这项研究包括461,183人,其中14.3%有PRISm和7.9%有AO. 在23年的时间里,有4038例肺癌病例和3314例肺癌死亡病例被记录.
- 与正常肺功能相比,患有PRISm和AO的个体患肺癌的发病率和死亡率风险显著更高.
- 对肺癌发病率和死亡率的调整后危险比率在整体队列和从未吸烟的小组中都较高,风险与肺功能障碍的严重程度成比例增加.
结论:
- 肺功能受损,包括PRISm和AO,与患肺癌的风险增加和随后的死亡率显著相关.
- 这些发现强调了将肺功能评估纳入肺癌查方案的重要性,以改善风险分层和候选人选择.
更多相关视频
相关概念视频
01:20Chronic Obstructive Pulmonary Disease-I: Introduction
2.8K
Chronic Obstructive Pulmonary Disease (COPD) is a long-lasting respiratory condition requiring continuous attention and care. It is a progressive lung disease that leads to breathing challenges due to airflow obstruction. It manifests as persistent respiratory symptoms and restricted airflow resulting from abnormalities in the airways and alveoli, usually due to long-term exposure to harmful particles or gases. COPD mainly consists of two primary conditions: emphysema and chronic bronchitis.
2.8K
01:20Chronic Obstructive Pulmonary Disease-II: Pathophysiology
2.8K
Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
Chronic Inflammation
2.8K
01:25Statistical Methods for Analyzing Epidemiological Data
363
Epidemiological data primarily involves information on specific populations' occurrence, distribution, and determinants of health and diseases. This data is crucial for understanding disease patterns and impacts, aiding public health decision-making and disease prevention strategies. The analysis of epidemiological data employs various statistical methods to interpret health-related data effectively. Here are some commonly used methods:
363
01:22Chronic Obstructive Pulmonary Disease
1.2K
COPD is defined as a heterogeneous lung condition marked by persistent respiratory symptoms such as dyspnea, cough, and sputum production, caused by abnormalities in the airways that cause airflow obstruction.
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
1.2K
01:25Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.
2.7K
Understanding the variety of primary symptoms and systemic complications that characterize chronic obstructive pulmonary disease (COPD) is crucial for healthcare professionals.
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:
2.7K
02:59Cancer Prevention
6.2K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
6.2K