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Updated: Jun 26, 2025

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COVID-19严重程度与烟草吸烟状态之间的关联:使用倾向性得分匹配权重分析的回顾性队列研究
Musaad A Alshammari1, Ahmad Alamer2, Lina Al Lehaibi3
1Department of Pharmacology and Toxicology, King Saud University, Riyadh, Saudi Arabia malshammari@ksu.edu.sa.
BMJ open respiratory research
|May 8, 2024
概括
吸烟史可能会增加严重COVID-19结果的风险,特别是需要氧气治疗. 需要进一步的研究来证实这些发现在更大的群体.
科学领域:
- 公共卫生 公共卫生
- 流行病学 流行病学
- 呼吸系统医学 呼吸系统医学
背景情况:
- COVID-19仍然是全球健康威胁,死亡率很高.
- 吸烟者面临严重的COVID-19并发症和死亡的风险增加.
- 这项研究检查了吸烟史对沙特阿拉伯COVID-19患者结果的影响.
研究的目的:
- 研究COVID-19患者吸烟史和不良临床结果之间的关联.
- 为了确定吸烟史是否与COVID-19的严重程度或死亡率增加有关.
主要方法:
- 447名COVID-19患者的回顾性观察队列研究 (2020年1月至12月).
- 纳入标准:已确诊COVID-19的成年人 (≥18岁);适用排除标准.
- 统计分析包括匹配权重和定向非循环图 (DAG) 的因果路径分析.
主要成果:
- 该样本包括126名经常吸烟者和321名从未吸烟者;平均年龄50岁,73.4%是男性.
- 经常吸烟者显示出更高的严重COVID-19几率的趋势 (OR1.44,p=0.130).
- 增加的几率与非侵入性氧气治疗有关 (OR1.05,p=0.101),在所有分析中一致.
结论:
- 研究结果表明,吸烟史可能与增加COVID-19不良结果的风险有关.
- 限制包括回顾性设计和小样本大小.
- 需要进一步的研究来验证这些关联.
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