间歇性禁食影响免疫力和新陈代谢
Daniel M Marko1, Meghan O Conn1, Jonathan D Schertzer1
1Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON, Canada; Farncombe Family Digestive Health Research Institute, McMaster University, Hamilton, ON, Canada; Centre for Metabolism, Obesity, and Diabetes Research, McMaster University, Hamilton, ON, Canada.
间歇性禁食 (IF) 影响免疫细胞代谢,改善代谢灵活性,减少肥胖和2型糖尿病 (T2D) 的炎症. 与卡路里限制相比,它通过影响免疫和代谢信号通路提供明显的好处.
科学领域:
- 免疫代谢过程中的免疫代谢.
- 细胞的新陈代谢
- 内分泌学 在内分泌学.
背景情况:
- 间歇性禁食 (IF) 影响了对代谢灵活性和肥胖和2型糖尿病 (T2D) 炎症至关重要的免疫代谢反应.
- 禁食期需要基质利用的转变,影响细胞能量通路.
- 肥胖和T2D的特点是代谢功能障碍和慢性炎症,为治疗干预创造了一个复杂的环境.
研究的目的:
- 审查IF的免疫代谢效应,将其与热量限制 (CR) 相比较.
- 为了阐明在禁食期间代谢和免疫细胞之间的通信.
- 探索疾病特异性免疫代谢如何影响IF结果,包括肠道微生物群的作用.
主要方法:
- 文献综述侧重于免疫代谢和间歇性禁食.
- 对禁食的细胞和组织特异反应的分析.
- 检查连接新陈代谢和免疫系统的信号通路.
主要成果:
- IF调节免疫代谢反应,增强代谢灵活性和减少炎症.
- 与CR不同,IF可以改善葡萄糖代谢和降低炎症,即使没有显著的体重减轻.
- 禁食诱导时间依赖的,分隔的免疫变化,涉及肝脏,脂肪组织,骨肌肉和免疫细胞.
结论:
- 间歇性禁食是一种独特的方法,通过向免疫代谢来管理代谢疾病.
- 了解代谢和免疫细胞之间的相互作用对于优化IF策略至关重要.
- 肠道微生物群在介导IF的代谢和免疫作用方面发挥着重要作用.
更多相关视频
08:30Intraperitoneal Glucose Tolerance Test, Measurement of Lung Function, and Fixation of the Lung to Study the Impact of Obesity and Impaired Metabolism on Pulmonary Outcomes
Published on: March 15, 2018
10:17An Advanced Murine Model for Nonalcoholic Steatohepatitis in Association with Type 2 Diabetes
Published on: April 26, 2019
相关概念视频
Metabolic States of the Body: Fasting and Starvation
Metabolic States of the Body: The Postabsorptive State
Initially, glycogen stored in the liver is broken down to release glucose into the bloodstream, while glycogen in the muscles is broken down to supply glucose for energy directly within the muscle cells. As glycogen stores diminish,...
Metabolic States of the Body: The Absorptive State
Overview of Carbohydrate Metabolism
Glucose transport into cells is facilitated by a family of transport proteins called GLUT (Glucose Transporters). GLUT4 is the primary glucose transporter for insulin-stimulated glucose...
Factors Affecting the Risk of Infection
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
Overview of Lipid Metabolism
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
