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Updated: Jun 26, 2025

Recapitulation of an Ion Channel IV Curve Using Frequency Components
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Published on: February 8, 2011

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TWIK1离子选择性对pH的动态反应的机制基础

Franck C Chatelain1,2, Nicolas Gilbert1,2, Delphine Bichet1,2

  • 1Université Côte d'Azur, Centre national de la recherche scientifique, Institut national de la santé et de la recherche médicale, Institut de pharmacologie moléculaire et cellulaire, 06560, Valbonne, France.

Nature communications
|May 8, 2024
PubMed
概括

当酸度增加时,TWIK1通道将其离子选择性从 (K+) 变为 (Na+). 分子动力学模拟揭示了特定的残留相互作用,驱动了这种依赖pH的结构转变.

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