甲状腺功能障碍驱动的骨损失取决于BMP受体Bmpr1a在骨质母细胞中的表达.
Franziska Lademann1, Eddy Rijntjes2, Josef Köhrle2
1Department of Medicine III & Center for Healthy Aging, Medical Faculty and University Hospital Carl Gustav Carus, Dresden University of Technology, Dresden, Germany.
Communications biology
|May 8, 2024
概括
甲状腺功能障碍症通过增加骨周转率导致骨质损失. 在骨质母细胞中阻止BMPR1A,但不阻止骨质母细胞,通过减少骨质再吸收和甲状腺激素诱导的活动来预防这种骨质疏松症.
科学领域:
- 内分泌学 在内分泌学.
- 骨生物学 骨生物学 骨生物学
- 细胞信号传递 细胞信号传递
背景情况:
- 甲状腺功能障碍会增加骨的循环,增加骨质疏松症的风险.
- 骨形态遗传蛋白 (BMP) 信号传递在骨代谢中起作用.
- 之前的研究表明,系统性BMPR1A阻断可以防止甲状腺过高的骨质损失.
研究的目的:
- 为了研究BMPR1A在甲状腺功能障碍引起的骨质疏松症中的细胞类型特定作用.
- 为了确定BMPR1A在骨质细胞或骨质原生细胞中被删除是否会影响骨质损失.
- 阐明BMPR1A影响甲状腺激素对骨细胞影响的机制.
主要方法:
- 产生的条件淘汰赛小鼠缺乏Bmpr1a在骨质细胞前体 (LysM-Cre) 或骨质原生子 (Osx-Cre).
- 在淘汰赛和野生型小鼠中诱导甲状腺功能障碍.
- 分析了骨的微观结构,强度和循环;对骨质细胞和骨质细胞活性进行了体外研究.
主要成果:
- 骨质细胞特异性Bmpr1a删除并没有防止甲状腺功能障碍引起的骨质损失.
- 骨质原生因子特异性Bmpr1a删除可以防止骨再吸收和骨质疏松的增加.
- 骨质母细胞中Bmpr1a的删除阻止了甲状腺激素诱导的分化,活性和Rankl/Opg比率的变化.
结论:
- 骨质母细胞BMPR1A是甲状腺功能升高引起的骨质疏松症的关键调解者.
- 骨质母细胞中的BMPR1A促进甲状腺激素驱动的骨质母细胞活动和合到骨质母细胞再吸收.
- 向骨质细胞BMPR1A可能为甲状腺功能增强骨质疏松症提供治疗策略.
更多相关视频
相关概念视频
Hormones and Bone Tissue
2.7K
The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
2.7K
Bone Remodeling
38.3K
Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
38.3K
Osteoclasts in Bone Remodeling
2.9K
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
2.9K
Bone Disorders
3.5K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
3.5K
Skeleton and Calcium Homeostasis
4.5K
Calcium is not only the most abundant mineral in bone but also the most abundant mineral in the human body. Calcium ions are needed for bone mineralization, tooth health, heart rate regulation and strength of contraction, blood coagulation, the contraction of smooth and skeletal muscle cells, and the regulation of nerve impulse conduction. The average calcium level in the blood is about 10 mg/dL. When the body cannot maintain this level, a person will experience hypo or hypercalcemia.
4.5K
Functions of Thyroid Hormones
2.7K
The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
2.7K


