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Updated: Jun 26, 2025

Induction of Murine Intestinal Inflammation by Adoptive Transfer of Effector CD4+CD45RBhigh T Cells into Immunodeficient Mice
08:37

Induction of Murine Intestinal Inflammation by Adoptive Transfer of Effector CD4+CD45RBhigh T Cells into Immunodeficient Mice

Published on: April 21, 2015

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通过转录网络分析,识别控制致病性CD4+ T细胞在炎症性肠病中的命运的主调节基因

José M Jiménez1, J Sebastián Contreras-Riquelme2, Pía M Vidal3

  • 1Centro Científico y Tecnológico de Excelencia Ciencia & Vida, Fundación Ciencia & Vida, Avenida Del Valle Norte #725, 8580702, Huechuraba, Santiago, Chile.

Scientific reports
|May 8, 2024
PubMed
概括

研究人员确定了关键的转录调节器,Lef1和Mybl2,在炎症性肠病 (IBD) 动物模型中驱动致病因子 CD4+ T 细胞行为. 这些发现为IBD治疗提供了潜在的新治疗点.

关键词:
CD4+ T 细胞是 CD4+ T 细胞.肠道炎症 肠道炎症炎症性肠道疾病 炎症性肠道疾病主调节基因,Lef1,Mybl2 这些基因

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