对微量元素的阐明:对发烧性发作中的血清度进行系统审查和元分析
Hamid Abbasi1,2, Sara Khoshdooz3, Mohammad Mehdi Abbasi4
1Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
Biological trace element research
|May 8, 2024
概括
与健康儿童相比,患有发烧 (FS) 的儿科患者表现出较低的关键微量元素血清度,包括,和. 这表明微量元素水平和FS的发生之间存在潜在的联系.
科学领域:
- 儿科神经学 儿科神经学
- 营养生物化学 营养生物化学
- 系统性审查和元分析
背景情况:
- 发烧性 (FS) 在儿童中很常见,通常是由高烧和感染引发的.
- 新出现的证据表明,血清微量元素度在FS发展中可能发挥作用.
- 了解这些关联可以为未来的研究和潜在的预防策略提供信息.
研究的目的:
- 系统地评估血清微量元素水平与儿科患者发烧性发作的发生之间的关联.
- 量化FS的和没有FS的儿童之间,,铜和的血清度差异.
主要方法:
- 进行了全面的元分析,搜索了四个主要数据库 (Scopus,科学网,PubMed,谷歌学者) 到2024年2月.
- 根据PICO框架 (患有FS的儿科患者,血清微量元素,比较组,FS发生率) 选择了研究.
- 使用纽卡斯尔-太华尺度 (NOS) 评估方法质量,从最初确定的168项研究中包括了37项研究.
主要成果:
- 与对照组相比,患有FS的儿童的血清含量 (SMD: -1.25) 和含量 (SMD: -2.23) 显著降低.
- 在FS组中也观察到较低的血清水平 (SMD: -0.76),尽管具有边界统计学意义.
- 相反,对照组的血清铜含量 (SMD:0.43) 比患有FS的儿童高.
结论:
- 这一元分析表明,患有发烧的儿科患者的血清含量改变了必需微量元素的度.
- 具体来说,较低的,和含量,以及可能更高的铜含量与FS相关.
- 需要进一步的研究,以阐明这些微量元素在发烧性发作的病变发生过程中的确切作用.
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